DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dong Sun Lee | - |
dc.contributor.author | Nam Soon Kim | - |
dc.contributor.author | Sang Han Lee | - |
dc.date.accessioned | 2017-04-19T08:57:49Z | - |
dc.date.available | 2017-04-19T08:57:49Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.24.727 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5405 | - |
dc.description.abstract | Glycosidases play a pivotal role in processing of various glycoproteins and glycolipids. It is well known that glycosidases are also involved in a variety of degenerative metabolic disorders such as cancer and AIDS. In order to develop potent α-glucosidase inhibitors, we first screened 2,2-diphenyl-1-picrylhydrazyl hydrate as a candidate. 2,2-Diphenyl-1-picrylhydrazyl hydrate was found to inhibit α- and β-glucosidases as well as α- and β-mannosidases. It was also shown to be a non-competitive inhibitor of yeast α-glucosidase with a Ki value of 1.1×10-6 M. Taken together, we anticipate that 2,2-diphenyl-1-picrylhydrazyl hydrate may be a potent inhibitor for some incurable metabolic disorders including AIDS. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | 2,2-diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an α-glycosidase inhibitor | - |
dc.title.alternative | 2,2-diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an α-glycosidase inhibitor | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 728 | - |
dc.citation.startPage | 727 | - |
dc.citation.volume | 24 | - |
dc.contributor.affiliatedAuthor | Nam Soon Kim | - |
dc.contributor.affiliatedAuthor | Sang Han Lee | - |
dc.contributor.alternativeName | 이동선 | - |
dc.contributor.alternativeName | 김남순 | - |
dc.contributor.alternativeName | 이상한 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 24, no. 6, pp. 727-728 | - |
dc.identifier.doi | 10.1248/bpb.24.727 | - |
dc.subject.keyword | 2,2-diphenyl-1-picrylhydrazyl hydrate | - |
dc.subject.keyword | α-glucosidase inhibitor | - |
dc.subject.keyword | enzyme kinetics | - |
dc.subject.keyword | non-competitive inhibition | - |
dc.subject.local | 2,2-diphenyl-1-picrylhydrazyl hydrate | - |
dc.subject.local | α-Glucosidase inhibitors | - |
dc.subject.local | α-Glucosidase inhibitor | - |
dc.subject.local | α-glucosidase inhibitor | - |
dc.subject.local | Enzyme kinetic | - |
dc.subject.local | Enzyme kinetics | - |
dc.subject.local | enzyme kinetics | - |
dc.subject.local | Non-competitive inhibition | - |
dc.subject.local | non-competitive inhibition | - |
dc.description.journalClass | Y | - |
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