2,2-diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an α-glycosidase inhibitor

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dc.contributor.authorDong Sun Lee-
dc.contributor.authorNam Soon Kim-
dc.contributor.authorSang Han Lee-
dc.date.accessioned2017-04-19T08:57:49Z-
dc.date.available2017-04-19T08:57:49Z-
dc.date.issued2001-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.24.727ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5405-
dc.description.abstractGlycosidases play a pivotal role in processing of various glycoproteins and glycolipids. It is well known that glycosidases are also involved in a variety of degenerative metabolic disorders such as cancer and AIDS. In order to develop potent α-glucosidase inhibitors, we first screened 2,2-diphenyl-1-picrylhydrazyl hydrate as a candidate. 2,2-Diphenyl-1-picrylhydrazyl hydrate was found to inhibit α- and β-glucosidases as well as α- and β-mannosidases. It was also shown to be a non-competitive inhibitor of yeast α-glucosidase with a Ki value of 1.1×10-6 M. Taken together, we anticipate that 2,2-diphenyl-1-picrylhydrazyl hydrate may be a potent inhibitor for some incurable metabolic disorders including AIDS.-
dc.publisherPharmaceutical Soc Japan-
dc.title2,2-diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an α-glycosidase inhibitor-
dc.title.alternative2,2-diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an α-glycosidase inhibitor-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number6-
dc.citation.endPage728-
dc.citation.startPage727-
dc.citation.volume24-
dc.contributor.affiliatedAuthorNam Soon Kim-
dc.contributor.affiliatedAuthorSang Han Lee-
dc.contributor.alternativeName이동선-
dc.contributor.alternativeName김남순-
dc.contributor.alternativeName이상한-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 24, no. 6, pp. 727-728-
dc.identifier.doi10.1248/bpb.24.727-
dc.subject.keyword2,2-diphenyl-1-picrylhydrazyl hydrate-
dc.subject.keywordα-glucosidase inhibitor-
dc.subject.keywordenzyme kinetics-
dc.subject.keywordnon-competitive inhibition-
dc.subject.local2,2-diphenyl-1-picrylhydrazyl hydrate-
dc.subject.localα-Glucosidase inhibitors-
dc.subject.localα-Glucosidase inhibitor-
dc.subject.localα-glucosidase inhibitor-
dc.subject.localEnzyme kinetic-
dc.subject.localEnzyme kinetics-
dc.subject.localenzyme kinetics-
dc.subject.localNon-competitive inhibition-
dc.subject.localnon-competitive inhibition-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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