Nucleotide sequence and phylogenetic analysis of long terminal repeats of human endogenous retrovirus K family(HERV-K) on human chromosomes

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dc.contributor.authorHeui Soo Kim-
dc.contributor.authorJoo Young Choi-
dc.contributor.authorWon Ho Lee-
dc.contributor.authorKyung Lib Jang-
dc.contributor.authorByung Hwa Hyun-
dc.date.accessioned2017-04-19T08:57:50Z-
dc.date.available2017-04-19T08:57:50Z-
dc.date.issued2000-
dc.identifier.issn1090-6592-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5407-
dc.description.abstractIt has been suggested that human endogenous retroviruses K family (HERV-K) has a role in disease, and solitary long terminal repeats (LTRs) of HERV-K have been potentially capable of affecting the expression of closely located genes. Using the human monochromosomes 8, 9, 17, and 18, with specific PCR primers, we identified thirty-four sequences of new HERV-K LTRs. Those LTR elements were analyzed phylogenetically with the human-specific HERV-K LTRs using neighbor-joining and maximum parsimony methods. Clones HKL8-5, HKL9-5, and HKL9-8 are related by more than 99% homology with the human-specific HERV-K LTRs. The HKL9-5 clone on chromosome 9 was 100% identical with the sequences of human-specific LTR, AC002400, on chromosome 16. The findings suggest that there has been recent proliferation, transposition, or chromosomal translocation of HERV-K LTR elements on human chromosomes.-
dc.titleNucleotide sequence and phylogenetic analysis of long terminal repeats of human endogenous retrovirus K family(HERV-K) on human chromosomes-
dc.title.alternativeNucleotide sequence and phylogenetic analysis of long terminal repeats of human endogenous retrovirus K family(HERV-K) on human chromosomes-
dc.typeArticle-
dc.citation.titleMicrobial Comparative Genomics-
dc.citation.number3-
dc.citation.endPage127-
dc.citation.startPage121-
dc.citation.volume5-
dc.contributor.affiliatedAuthorByung Hwa Hyun-
dc.contributor.alternativeName김희수-
dc.contributor.alternativeName최주영-
dc.contributor.alternativeName이원호-
dc.contributor.alternativeName장경립-
dc.contributor.alternativeName현병화-
dc.identifier.bibliographicCitationMicrobial Comparative Genomics, vol. 5, no. 3, pp. 121-127-
dc.identifier.doi10.1089/omi.1.2000.5.121-
dc.description.journalClassN-
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