Involvement of acetyl phosphate in the in vivo activation of the response regulator ComA in Bacillus subtilis

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dc.contributor.authorSeong Bin Kim-
dc.contributor.authorByung Sik Shin-
dc.contributor.authorSoo Keun Choi-
dc.contributor.authorChi Kyung Kim-
dc.contributor.authorSeung Hwan Park-
dc.date.accessioned2017-04-19T08:57:50Z-
dc.date.available2017-04-19T08:57:50Z-
dc.date.issued2001-
dc.identifier.issn0378-1097-
dc.identifier.uri10.1016/S0378-1097(01)00008-8ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5409-
dc.description.abstractDevelopment of genetic competence in Bacillus subtilis is regulated by ComP-ComA, a two-component signal transduction system. The response regulator ComA is primarily activated by ComP, a histidine kinase that mediates response to nutrient conditions and cell density, and the activated ComA is required for transcription of the srf operon, which is essential for the development of genetic competence and surfactin production. In this study we suggested that the ComA could also be activated by a small molecule phospho-donor, acetyl phosphate. Examination of srfA-lacZ expression indicated that a significant amount of srfA expression still occurs in the comP mutant during growth in a sporulation medium containing excess glucose. Analysis of a comP and pta mutant suggests that srfA activation seen in the comP mutant is dependent on the expression of pta, which encodes phosphotransacetylase (Pta). As Pta is responsible for the catalysis for conversion of acetyl coenzyme A to acetyl phosphate, we conclude that the expression of srfA seen in the comP mutant is mainly due to the activation of ComA by acetyl phosphate.-
dc.publisherOxford Univ Press-
dc.titleInvolvement of acetyl phosphate in the in vivo activation of the response regulator ComA in Bacillus subtilis-
dc.title.alternativeInvolvement of acetyl phosphate in the in vivo activation of the response regulator ComA in Bacillus subtilis-
dc.typeArticle-
dc.citation.titleFEMS Microbiology Letters-
dc.citation.number2-
dc.citation.endPage183-
dc.citation.startPage179-
dc.citation.volume195-
dc.contributor.affiliatedAuthorSeong Bin Kim-
dc.contributor.affiliatedAuthorByung Sik Shin-
dc.contributor.affiliatedAuthorSoo Keun Choi-
dc.contributor.affiliatedAuthorSeung Hwan Park-
dc.contributor.alternativeName김성빈-
dc.contributor.alternativeName신병식-
dc.contributor.alternativeName최수근-
dc.contributor.alternativeName김치경-
dc.contributor.alternativeName박승환-
dc.identifier.bibliographicCitationFEMS Microbiology Letters, vol. 195, no. 2, pp. 179-183-
dc.identifier.doi10.1016/S0378-1097(01)00008-8-
dc.subject.keywordtwo-component signal transduction-
dc.subject.keywordComA-
dc.subject.keywordacetyl phosphate-
dc.subject.keywordsrfA-lacZ-
dc.subject.keywordbacillus subtilis-
dc.subject.localtwo-component signal transduction-
dc.subject.localComA-
dc.subject.localacetyl phosphate-
dc.subject.localAcetyl phosphate-
dc.subject.localsrfA-lacZ-
dc.subject.localBacillus subtilis-
dc.subject.localbacillus subtilis-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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