Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases

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dc.contributor.authorS H Kim-
dc.contributor.authorW H Lee-
dc.contributor.authorB S Kwon-
dc.contributor.authorGoo Taeg Oh-
dc.contributor.authorY H Choi-
dc.contributor.authorJ E Park-
dc.date.accessioned2017-04-19T08:57:53Z-
dc.date.available2017-04-19T08:57:53Z-
dc.date.issued2001-
dc.identifier.issn00471828-
dc.identifier.uri10.1253/jcj.65.136ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5431-
dc.description.abstractImmunohistochemical staining of human atherosclerotic plaques revealed expression of the tumor necrosis factor receptor superfamily (TNFRSF) 12 in regions rich in macrophage/foam cells. The role of TNFRSF12 in the functioning of monocytes in relation to atherogenesis was investigated by analysis of cellular events after stimulation of TNFRSF12 in a human macrophage-like cell line, THP-1. Activation of the THP-1 cells on plates coated with monoclonal antibody against TNFRSF12 induced the expression of matrix metalloproteinases (MMPs) -1, -9, and -13. Furthermore, the expression patterns of TNFRSF12 and the MMPs overlapped in atherosclerotic plaques. Signaling of TNFRSF12 may thus contribute to the induction of extracellular matrix degrading enzymes in macrophages.-
dc.titleTumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases-
dc.title.alternativeTumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases-
dc.typeArticle-
dc.citation.titleJapanese Circulation Journal-
dc.citation.number2-
dc.citation.endPage138-
dc.citation.startPage136-
dc.citation.volume65-
dc.contributor.alternativeName-
dc.contributor.alternativeName이원하-
dc.contributor.alternativeName-
dc.contributor.alternativeName오구택-
dc.contributor.alternativeName최윤호-
dc.contributor.alternativeName박정의-
dc.identifier.bibliographicCitationJapanese Circulation Journal, vol. 65, no. 2, pp. 136-138-
dc.identifier.doi10.1253/jcj.65.136-
dc.subject.keywordatherosclerosis-
dc.subject.keywordmatrix metalloproteinase-
dc.subject.keywordtumor necrosis factor receptor superfamily-
dc.subject.localatherosclerosis-
dc.subject.localAtherosclerosis-
dc.subject.localmatrix metalloproteinase-
dc.subject.localMatrix metalloproteinase-
dc.subject.localtumor necrosis factor receptor superfamily-
dc.description.journalClassN-
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