Inhibition of glucocorticoid-mediated, caspase-independent dendritic cell death by CD40 activation

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorKwang Dong Kim-
dc.contributor.authorYong Kyung Choe-
dc.contributor.authorIn Seong Choe-
dc.contributor.authorJong Seok Lim-
dc.date.accessioned2017-04-19T08:57:53Z-
dc.date.available2017-04-19T08:57:53Z-
dc.date.issued2001-
dc.identifier.issn0741-5400-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5432-
dc.description.abstractGlucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on a variety of immune cells, including T cells, monocytes/macrophages, osteoclasts, and dendritic cells (DC). However, the mechanism(s) by which GC exert anti-inflammatory effects is still largely unknown. It is already well known that GC treatment inhibits DC maturation and interleukin (IL)-12 production by DC. In this study, we investigated the apoptosis induction of DC by a synthetic GC, dexamethasone (Dex). The stimulation with Dex resulted in DC apoptosis in a dose- and time-dependent manner as it was measured by determining annexin V-positive cells and mitochondrial potential. In contrast, monocytes that are precursor cells of DC are resistant to Dex-mediated apoptosis. The Dex-induced apoptosis of DC was independent of caspase activation because it was not inhibited by the broad caspase inhibitor, Z-VAD-fmk. It is interesting that agonistic CD40 antibody completely inhibited Dex-induced cell death, whereas other inflammatory stimuli did not show the same effect, suggesting that CD40 signaling may selectively modulate GC-mediated DC apoptosis. Taken together, our findings revealed an important role of GC and CD40 signaling in the regulation of immune responses in which DC play a key role in the inflammatory process of various immunomediated diseases.-
dc.publisherWiley-
dc.titleInhibition of glucocorticoid-mediated, caspase-independent dendritic cell death by CD40 activation-
dc.title.alternativeInhibition of glucocorticoid-mediated, caspase-independent dendritic cell death by CD40 activation-
dc.typeArticle-
dc.citation.titleJournal of Leukocyte Biology-
dc.citation.number3-
dc.citation.endPage434-
dc.citation.startPage426-
dc.citation.volume69-
dc.contributor.affiliatedAuthorYong Kyung Choe-
dc.contributor.affiliatedAuthorIn Seong Choe-
dc.contributor.affiliatedAuthorJong Seok Lim-
dc.contributor.alternativeName김광동-
dc.contributor.alternativeName최용경-
dc.contributor.alternativeName최인성-
dc.contributor.alternativeName임종석-
dc.identifier.bibliographicCitationJournal of Leukocyte Biology, vol. 69, no. 3, pp. 426-434-
dc.subject.keywordCD40 signaling-
dc.subject.keyworddexamethasone-
dc.subject.keywordapoptosis-
dc.subject.localCD40 signaling-
dc.subject.localdexamethasone-
dc.subject.localDexamethasone-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.