Carbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages

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dc.contributor.authorSun Duck Jeon-
dc.contributor.authorJong Seok Lim-
dc.contributor.authorChang Kiu Moon-
dc.date.accessioned2017-04-19T08:57:54Z-
dc.date.available2017-04-19T08:57:54Z-
dc.date.issued2001-
dc.identifier.issn03784274-
dc.identifier.uri10.1016/S0378-4274(00)00307-6ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5439-
dc.description.abstractThe effects of carbofuran (2,3-dihydro-2,2-dimethyl-7-benzo-furanol N-methylcarbamate) on the functions of T cells in splenocytes and peritoneal macrophages were examined in view of T-cell-mediated immune response (CMIR) in male C57BL/6 mice. Intraperitoneal administration of carbofuran (0.075, 0.15 and 0.3 mg/kg body weight) resulted in significant suppression of delayed type hypersensitivity (DTH), indicating that it caused the suppression of CMIR. Carbofuran decreased Concanavalin A (Con A)- and alloantigen-induced proliferation, and interleukin (IL)-2 production of splenocytes. In vitro addition of rIL-2 could not completely restore the suppressed T-cell proliferation, and IL-2-induced proliferation of Con A-activated splenocytes was also suppressed, which implied that carbofuran caused defects in IL-2 production and responsiveness of splenocytes to IL-2, leading to the suppression of T-cell proliferation. Con A-induced production of interferon-γ (IFN-γ) was significantly suppressed by carbofuran, while that of IL-4 was not affected. The production of transforming growth factor-β from splenocytes was also significantly inhibited by carbofuran. Judging from these results, carbofuran might directly suppress the cytokine production in T helper 1 (Th1) cells. In addition, IFN-γ-induced production of nitric oxide (NO) in macrophages was also inhibited by carbofuran, which might be one of the important mechanisms of carbofuran-induced CMIR suppression in mice. Collectively, the present study suggests that carbofuran might suppress CMIR through the suppression of T-cell responsiveness, IFN-γ production in Th1 cells, and NO generation in macrophages.-
dc.publisherElsevier-
dc.titleCarbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages-
dc.title.alternativeCarbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages-
dc.typeArticle-
dc.citation.titleToxicology Letters-
dc.citation.number2-
dc.citation.endPage155-
dc.citation.startPage143-
dc.citation.volume119-
dc.contributor.alternativeName전선덕-
dc.contributor.alternativeName임종석-
dc.contributor.alternativeName문창규-
dc.identifier.bibliographicCitationToxicology Letters, vol. 119, no. 2, pp. 143-155-
dc.identifier.doi10.1016/S0378-4274(00)00307-6-
dc.subject.keywordcarbofuran-
dc.subject.keywordcell-mediated immune responses-
dc.subject.keyworddelayed type hypersensitivity-
dc.subject.keywordsplenocytes-
dc.subject.keywordmixed lymphocyte reaction-
dc.subject.keywordcytokines-
dc.subject.keywordnitric oxide-
dc.subject.keywordmacrophages-
dc.subject.localcarbofuran-
dc.subject.localcell-mediated immune responses-
dc.subject.localdelayed type hypersensitivity-
dc.subject.localsplenocytes-
dc.subject.localmixed lymphocyte reaction-
dc.subject.localcytokines-
dc.subject.localnitric oxide-
dc.subject.localNitric oxide (NO)-
dc.subject.localmacrophages-
dc.subject.localmacrophage-
dc.description.journalClassY-
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