Negative regulation of yy1 transcription factor on the dynamin i gene promoter

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Title
Negative regulation of yy1 transcription factor on the dynamin i gene promoter
Author(s)
Ji Yun Yoo; Moon Jin Jeong; Sang Seop Lee; Kyung Im Lee; Byoung Mog Kwon; Young Mee Park; Mi Young Han
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 283, no. 2, pp. 340-343
Publication Year
2001
Abstract
Dynamin I is highly expressed in brain and plays a critical role in clathrin-mediated endocytosis and synaptic vesicle recycling. To elucidate the molecular mechanism by which expression of dynamin I is tissue-specifically regulated, we previously cloned and characterized the promoter of the mouse dynamin I gene and suggested that there is a negative regulatory element in this promoter region. In the present study, we showed that YY1 binds to this negative regulatory element located at -111 to -107 by using the EMSA and supershift analyses. Cotransfection experiment using an YY1 expression vector revealed that YY1 exerts a repressive role on the dynamin I gene promoter activity. These results demonstrate that transcription factor YY1 negatively regulates dynamin I expression via binding to the negative regulatory element.
Keyword
dynamin IpromoterYY1
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1006/bbrc.2001.4784
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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