Rkp1/Cpc2, a fission yeast rACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling
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- Rkp1/Cpc2, a fission yeast rACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling
- Mi Sun Won; Seung Kiel Park; Kwang Lae Hoe; Young Joo Jang; Kyung Sook Chung; Dong Uk Kim; Hyung Bae Kim; Hyang Sook Yoo
- Bibliographic Citation
- Biochemical and Biophysical Research Communications, vol. 282, no. 1, pp. 10-15
- Publication Year
- The Rkp1/Cpc2, a fission yeast RACK1 homolog, interacted with Pck2, one of the known PKC homologs, in vivo and in vitro. The rkp1-deletion mutants (Δrkp1) are elongated and the pck2-deletion mutant (Δpck2) showed abnormal morphology. The double-deletion mutant (Δrkp1Δpck2) showed more aberrant cell shapes and was sensitive to high salt concentration. Both Δrkp1 and Δpck2 cells were sensitive to latrunculin B (Lat B) which inhibits actin polymerization. The cells expressing the human RACK1 homolog complemented the latrunculin B sensitivity of Δrkp1 indicating that human RACK1 is a functional homolog of Rkp1/Cpc2. We propose that Rkp1/Cpc2 may function as a receptor for Pck2 in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis of Schizosaccharomyces pombe.
- Pck2actin cytoskeletonS. pombeRkp1Cpc2
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- Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Research on National Challenges > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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