Up-regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis

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Title
Up-regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis
Author(s)
Jae Wha Kim; Ae Ran Moon; Joo Heon Kim; Sun Young Yoon; Goo Taeg Oh; Yong Kyung Choe; In Seong Choe
Bibliographic Citation
Molecules and Cells, vol. 11, no. 2, pp. 151-157
Publication Year
2001
Abstract
The cDNA clones, which were highly expressed in liver tissues of hepatocellular carcinoma (HCC) patients, were identified using dot hybridization and reconfirmed by Northern blot analysis. One of the clones, ninjurin (nerve injury induced protein), showed a much higher expression level in the liver tissue of HCC patients than in normal liver tissue. Interestingly, the presence of ninjurin mRNA transcripts was detected with high intensity in HCC tissues when combined with viral infection and cirrhosis, but not with a normal liver or HCC tissue unrelated with viral infection and cirrhosis. We produced a N-terminal part of recombinant ninjurin protein, as well as a monoclonal antibody specific to this polypeptide. The intensity of immunohistochemical staining of the liver tumor tissue, and regenerating tissue for the ninjurin protein, was stronger than that of normal liver tissue. These results suggest that ninjurin may play an important role in the development of HCC combined with cirrhosis and viral infection.
Keyword
chronic Hepatitiscirrhotic liver tissueshepatocellular carcinomaliver regenerationup-regulation of ninjurin expression
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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