Coumarins from the roots of Angelica decursiva-albiflora = 개바디 뿌리의 쿠마린성분

Abstract

From the root of Angelica decursiva-albiflora Yook, which has been used as a folk medicine for a sedative, analgesic and expectorant, four free coumarins, e.g., decursidin(I), decursin(II), umbelliferone (III) and nodakenetin (IV), and two coumarin glycosides, e.g., nodakenin (V) and decuroside I(VI) were isolated. The cytotoxicity of nodakenin(V) against L-1210 leukemia cells was less effective than cisplatin, but in the nephrotoxicity against rabbit kidney proximal tubular cell nodakenin(V) showed remarkably less nephrotoxicant than cisplatin.