The Neuron Restrictive Silencer Factor Can Act as an Activator for Dynamin I Gene Promoter Activity in Neuronal Cells

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Title
The Neuron Restrictive Silencer Factor Can Act as an Activator for Dynamin I Gene Promoter Activity in Neuronal Cells
Author(s)
Ji Yun Yoo; Moon Jin Jeong; Sang Seop Lee; Kyung Im Lee; Byoung Mog Kwon; Dong Sun Kim; Young Mee Park; Mi Young Han
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 283, no. 4, pp. 928-932
Publication Year
2001
Abstract
The neuron restrictive silencer element (NRSE) has been identified in several neuronal genes and confers neuron specificity by silencing transcription in nonneuronal cells. We have previously reported that Sp1 and an NF-κB-like element (NE-1) are required for the promoter activity of mouse dynamin I gene. In the present study, we found that the upstream regulatory region of the dynamin I promoter has an NRSE-like sequence and showed that neuron restrictive silencer factor (NRSF) binds to this element in neuronal cells as well as in nonneuronal cells. We also showed that NRSF activates the promoter activity of dynamin I gene in neuronal cells. From the results in this study, we suggest that NRSE might be involved in the neuron restriction of dynamin I expression, and NRSF could act as an activator for promoter activity of dynamin I gene in neuronal cells.
Keyword
dynamin IpromoterNRSENRSFNS20Y cells
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1006/bbrc.2001.4857
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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