Syntheses of certain 3-Aryl-2-propenoates and evaluation of their cytotoxicity

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Title
Syntheses of certain 3-Aryl-2-propenoates and evaluation of their cytotoxicity
Author(s)
Nguyen-Hai Nam; Young Jae You; Yong Kim; Dong Ho Hong; Hwan Mook Kim; Byung Zun Ahn
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 11, no. 9, pp. 1173-1176
Publication Year
2001
Abstract
A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0960-894X(01)00165-2
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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