Effect of genistein analogs on oxygen radical production in leukocytes stimulated by unopsonized zymosan

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Title
Effect of genistein analogs on oxygen radical production in leukocytes stimulated by unopsonized zymosan
Author(s)
Ji Eun Yun; Sei Ryang Oh; Hyeong Kyu Lee; I M Chang; K Takatsu; Y P Yun; K R Min; Y Kim
Bibliographic Citation
Planta Medica, vol. 67, no. 3, pp. 274-276
Publication Year
2001
Abstract
Effects of genistein analogs on oxygen radical production have been analyzed in human neutrophils, human monocytes or murine macrophages Raw264.7 stimulated with unopsonized zymosan by lucigenin- and luminol-enhanced chemiluminescence assays. Genistein exhibited IC50 values of 10.7-11.5 μM on the oxygen radical production in human neutrophils, 10.9-11.0 μM in human monocytes, and 14.8-27.3 μM in Raw264.7 cells. Orobol, a genistein analog with an additional hydroxy group at the 3' position, exhibited IC50 values of 3.0-3.3 μM on the oxygen radical production in human neutrophils, 2.8-3.1 μM in human monocytes, and 1.5-3.9 μM in Raw264.7 cells. Genistin and sophoricoside are genistein glycosides with a glucose moiety at 7 or 4′ position, respectively. The genistein glycosides exhibited 23-37% inhibitory effects at 100 μM on the oxygen radical production.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2001-12002
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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