DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang Hee Hong | - |
dc.contributor.author | Seo Ok Oh | - |
dc.contributor.author | Michael Lee | - |
dc.contributor.author | Young Rok Kim | - |
dc.contributor.author | Dong Uk Kim | - |
dc.contributor.author | Gang Min Hur | - |
dc.contributor.author | Jae Heun Lee | - |
dc.contributor.author | Kyu Lim | - |
dc.contributor.author | Byung Doo Hwang | - |
dc.contributor.author | Seung Kiel Park | - |
dc.date.accessioned | 2017-04-19T08:58:01Z | - |
dc.date.available | 2017-04-19T08:58:01Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | 10.1006/bbrc.2001.4517 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5495 | - |
dc.description.abstract | We made stable cell lines overexpressing PLD1 (GP-PLD1) from GP+envAm12 cell, a derivative of NIH 3T3 cell. PLD1 activity and extracellular signal-regulated kinase (ERK) phosphorylation were enhanced in GP-PLD1 cells by the treatment of lysophosphatidic acid (LPA). In contrast, these LPA-induced effects were attenuated with the pretreatment of pertussis toxin (PTX) or protein kinase C (PKC) inhibitor. Moreover, accumulation of phosphatidic acid (PA), a product of PLD action, potentiated the LPA-induced ERK activation in GP-PLD1 cells while blocking of PA production with the treatment of 1-butanol attenuated LPA-induced ERK phosphorylation. From these results, we suggest that LPA activate PLD1 through pertussis toxin-sensitive G protein and PKC-dependent pathways, then PA produced from PLD1 activation facilitate ERK phosphorylation. | - |
dc.publisher | Elsevier | - |
dc.title | Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid | - |
dc.title.alternative | Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 1342 | - |
dc.citation.startPage | 1337 | - |
dc.citation.volume | 281 | - |
dc.contributor.affiliatedAuthor | Michael Lee | - |
dc.contributor.affiliatedAuthor | Dong Uk Kim | - |
dc.contributor.alternativeName | 홍장희 | - |
dc.contributor.alternativeName | 오세옥 | - |
dc.contributor.alternativeName | 이미가엘 | - |
dc.contributor.alternativeName | 김영래 | - |
dc.contributor.alternativeName | 김동욱 | - |
dc.contributor.alternativeName | 허강민 | - |
dc.contributor.alternativeName | 이재흔 | - |
dc.contributor.alternativeName | 임규 | - |
dc.contributor.alternativeName | 황병두 | - |
dc.contributor.alternativeName | 박승길 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 281, no. 5, pp. 1337-1342 | - |
dc.identifier.doi | 10.1006/bbrc.2001.4517 | - |
dc.subject.keyword | phospholipase D | - |
dc.subject.keyword | mitogen activated protein kinase | - |
dc.subject.keyword | phosphatidic acid | - |
dc.subject.keyword | protein kinase C | - |
dc.subject.keyword | lysophosphatidic acid | - |
dc.subject.keyword | Gi protein | - |
dc.subject.local | Phospholipase D | - |
dc.subject.local | phospholipase D | - |
dc.subject.local | mitogen activated protein kinase | - |
dc.subject.local | mitogen-activated protein kinase | - |
dc.subject.local | mitogen-activated protein kinases | - |
dc.subject.local | Mitogen activated protein kinase | - |
dc.subject.local | Mitogen-acti-vated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinase (MAPK) | - |
dc.subject.local | Mitogen-activated protein kinases | - |
dc.subject.local | Mitogen-activated protein kinases (MAPKs) | - |
dc.subject.local | Mitogen-activated protein (MAP) kinase | - |
dc.subject.local | Mitogenactivated protein kinase | - |
dc.subject.local | phosphatidic acid | - |
dc.subject.local | Protein kinase C | - |
dc.subject.local | protein kinase C | - |
dc.subject.local | protein kinase c | - |
dc.subject.local | lysophosphatidic acid | - |
dc.subject.local | Lysophophatidic acid | - |
dc.subject.local | Lysophosphatidic acid | - |
dc.subject.local | Gi protein | - |
dc.description.journalClass | Y | - |
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