Anti-invasive activity of torilin, a sesquiterpene compound isolated from Torilis japonica

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Title
Anti-invasive activity of torilin, a sesquiterpene compound isolated from Torilis japonica
Author(s)
M S Kim; J H Baek; M T Park; T K Sohn; S E Kim; Jung Joon Lee; K W Kim
Bibliographic Citation
Oncology Reports, vol. 8, no. 2, pp. 359-364
Publication Year
2001
Abstract
Torilin is a sesquiterpene compound purified from Torilis japonica (Umbdliferae). We have previously reported that torilin has a potent anti-angiogenic activity both in vivo and in vitro. In the present study, we investigated the anti-invasive activity of torilin, and interestingly found that torilin completely blocked intravasation of HT1080 human fibrosarcoma cells inoculated on the chorioallantoic membrane (CAM) of chick embryo. In addition, torilin decreased the attachment of HT1080 cells to confluent human umbilical vein endothelial cells (HUVECs) at nontoxic concentration. In in vitro transwell invasion model, 25 μM torilin also significantly inhibited HT1080 cell invasion in a time-dependent manner. Activity and expression of matrix metalloproteinase-9 (MMP-9) that is very important in tumor invasion and metastasis were also decreased by torilin treatment, indicating that the inhibitory effect of torilin on invasion of HT1080 cells may result from decreasing activity and expression of MMP-9. Therefore, it is possible that torilin may decrease metastatic potential of tumor cells through inhibiting their attachment to endothelial cells and intravasation to blood vessels. Taken together, torilin may have a strong activity to suppress tumorigenesis by inhibition of tumor invasion.
Keyword
Alu PCRHT1080 cellsinvasiontorilin
ISSN
1021-335X
Publisher
Spandidos Publ Ltd
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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