Synthesis and in vitro evaluation of 3-substituted-1-azaanthraquinones

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Title
Synthesis and in vitro evaluation of 3-substituted-1-azaanthraquinones
Author(s)
Hee Soon Lee; Seoung Soo Hong; Young Ho Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 6, no. 8, pp. 933-936
Publication Year
1996
Abstract
In the course of developing novel antitumor agents, we synthesized 3-substituted-1-azaanthraquinones incorporating the alkylating or latent alkylating substituents as potential antitumor agents. The most active compound 4 exhibited cytotoxic activity comparable to that of doxorubicin. The compounds 3-8 retained much of their activity against the doxorubicin-resistant cell line (MCF7/R).
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/0960-894X(96)00156-4
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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