Preparation of Enantiomerically Pure (R)-2-Butyryloxymethylglycidol by Lipase-Catalyzed Asymmetric Hydrolysis

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Title
Preparation of Enantiomerically Pure (R)-2-Butyryloxymethylglycidol by Lipase-Catalyzed Asymmetric Hydrolysis
Author(s)
Young Bae Seu; Taeg Kyeong Lim; Chang Jin Kim; Sun Chul Kang
Bibliographic Citation
Tetrahedron : Asymmetry, vol. 6, no. 12, pp. 3009-3014
Publication Year
1995
Abstract
Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol 3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95% of chemical yield.
ISSN
0957-4166
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/0957-4166(95)00397-5
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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