Mechanism of interferon-γ down-regulation of the interleukin 4-induced cd23/fcεrii expression in human B-cells : post-transcriptional modulation by interferon-γ

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dc.contributor.authorChoong Eun Lee-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorKwang Ho Pyun-
dc.date.accessioned2017-04-19T08:58:11Z-
dc.date.available2017-04-19T08:58:11Z-
dc.date.issued1993-
dc.identifier.issn0161-5890-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5515-
dc.description.abstractIt has been reported that the interleukin 4 (IL-4) specific induction of cell surface CD23 (Fc(ε)RII) is due down-regulated by interferon-γ (IFN-γ) in monocytes and B cells. However, the molecular level at which the inhibition occurs seems to vary depending on the cell types. In normal human B cells, IFN-γ inhibits the IL-4 induced de novo synthesis of CD23 at the level of gene expression. Analysis of inhibition kinetics suggested a rapid signal transmission by IFN-γ. Yet the inhibitory action of IFN-γ on CD23 mRNA accumulation appeared as a secondary response requiring a new protein synthesis. Through nuclear run-on transcription and mRNA stability studies, we further demonstrate that the IL-4 induced CD23 gene expression is down-regulated by IFN-γ mainly at post-transcriptional levels by decreasing mRNA stability.-
dc.publisherElsevier-
dc.titleMechanism of interferon-γ down-regulation of the interleukin 4-induced cd23/fcεrii expression in human B-cells : post-transcriptional modulation by interferon-γ-
dc.title.alternativeMechanism of interferon-γ down-regulation of the interleukin 4-induced cd23/fcεrii expression in human B-cells : post-transcriptional modulation by interferon-γ-
dc.typeArticle-
dc.citation.titleMolecular Immunology-
dc.citation.number3-
dc.citation.endPage307-
dc.citation.startPage301-
dc.citation.volume30-
dc.contributor.affiliatedAuthorChoong Eun Lee-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorKwang Ho Pyun-
dc.contributor.alternativeName이충은-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName변광호-
dc.identifier.bibliographicCitationMolecular Immunology, vol. 30, no. 3, pp. 301-307-
dc.identifier.doi10.1016/0161-5890(93)90058-J-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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