Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic acat and aortic vcam-1 and mcp-1 in high cholesterol-fed rabbits

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Title
Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic acat and aortic vcam-1 and mcp-1 in high cholesterol-fed rabbits
Author(s)
Chul Ho LeeTae Sook Jeong; Yang Kyu Choi; Byung Hwa Hyun; Goo Taeg Oh; Eun Hee Kim; Ju Ryoung Kim; Jang Il Han; Song Hae Bok
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 284, no. 3, pp. 681-688
Publication Year
2001
Abstract
The anti-atherogenic effects of the citrus flavonoids, naringin and naringenin, were evaluated in high cholesterol-fed rabbits. At 3 months of age, 30 male New Zealand White (NZW) rabbits were divided into three groups (n=10 per group). The rabbits were fed a 1% cholesterol diet alone (control group) or a diet supplemented with either 0.1% naringin or 0.05% naringenin for 8 weeks. The plasma lipoprotein levels, total cholesterol, triglyceride, and high-density lipoprotein showed no significant differences in the control and experimental groups. Hepatic acyl-CoA: cholesterol acyltransferase (ACAT) activity was slightly low in naringin (5.0%)- and naringenin (15.0%)-fed rabbits, compared to control group. The aortic fatty streak areas were significantly lower in both the naringin (19.2 ± 5.6%)- and naringenin (18.1 ± 6.5%)-supplemented groups than in the control group (60.4 ± 14.0%). The expression levels of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1), by semiquantitative RT-PCR analysis of the thoracic aorta, were significantly lower in the flavonoids supplemented groups than in the control group. These results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.
Keyword
naringinnaringeninfatty streakACATMCP-1VCAM-1
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1006/bbrc.2001.5001
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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