Differential inheritance modes of DNA methylation between euchromatic and heterochromatic DNA sequences in ageing fetal bovine fibroblasts
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yong Kook Kang | - |
| dc.contributor.author | Deog Bon Koo | - |
| dc.contributor.author | Jung Sun Park | - |
| dc.contributor.author | Young Hee Choi | - |
| dc.contributor.author | Kyung Kwang Lee | - |
| dc.contributor.author | Yong Mahn Han | - |
| dc.date.accessioned | 2017-04-19T08:58:16Z | - |
| dc.date.available | 2017-04-19T08:58:16Z | - |
| dc.date.issued | 2001 | - |
| dc.identifier.issn | 0014-5793 | - |
| dc.identifier.uri | 10.1016/S0014-5793(01)02472-3 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5532 | - |
| dc.description.abstract | To elucidate overall changes in DNA methylation occurring by inappropriate epigenetic control during ageing, we compared fetal bovine fibroblasts and their aged neomycin-resistant versions using bisulfite-PCR technology. Reduction in DNA methylation was observed in euchromatic repeats (18S-rRNA/art2) and promoter regions of single-copy genes (the cytokeratin/β-lactoglobulin/interleukin-13 genes). Contrastingly, a stable maintenance of DNA methylation was revealed in various heterochromatic sequences (satellite I/II/alphoid and Bov-B). The differential inheritance mode of DNA methylation was confirmed through the analysis of individual neomycin-resistant clones. These global, multi-locus analyses provide evidence on the tendency of differential epigenetic modification between genomic DNA regions during ageing. | - |
| dc.publisher | Wiley | - |
| dc.title | Differential inheritance modes of DNA methylation between euchromatic and heterochromatic DNA sequences in ageing fetal bovine fibroblasts | - |
| dc.title.alternative | Differential inheritance modes of DNA methylation between euchromatic and heterochromatic DNA sequences in ageing fetal bovine fibroblasts | - |
| dc.type | Article | - |
| dc.citation.title | FEBS Letters | - |
| dc.citation.number | 1 | - |
| dc.citation.endPage | 5 | - |
| dc.citation.startPage | 1 | - |
| dc.citation.volume | 498 | - |
| dc.contributor.affiliatedAuthor | Yong Kook Kang | - |
| dc.contributor.affiliatedAuthor | Deog Bon Koo | - |
| dc.contributor.affiliatedAuthor | Jung Sun Park | - |
| dc.contributor.affiliatedAuthor | Young Hee Choi | - |
| dc.contributor.affiliatedAuthor | Kyung Kwang Lee | - |
| dc.contributor.affiliatedAuthor | Yong Mahn Han | - |
| dc.contributor.alternativeName | 강용국 | - |
| dc.contributor.alternativeName | 구덕본 | - |
| dc.contributor.alternativeName | 박정선 | - |
| dc.contributor.alternativeName | 최영희 | - |
| dc.contributor.alternativeName | 이경광 | - |
| dc.contributor.alternativeName | 한용만 | - |
| dc.identifier.bibliographicCitation | FEBS Letters, vol. 498, no. 1, pp. 1-5 | - |
| dc.identifier.doi | 10.1016/S0014-5793(01)02472-3 | - |
| dc.subject.keyword | ageing | - |
| dc.subject.keyword | methylation | - |
| dc.subject.keyword | epigenetic modification | - |
| dc.subject.keyword | euchromatin | - |
| dc.subject.keyword | heterochromatin | - |
| dc.subject.local | ageing | - |
| dc.subject.local | Ageing | - |
| dc.subject.local | methylation | - |
| dc.subject.local | Methylation | - |
| dc.subject.local | Epigenetic modification | - |
| dc.subject.local | epigenetic modification | - |
| dc.subject.local | euchromatin | - |
| dc.subject.local | heterochromatin | - |
| dc.description.journalClass | Y | - |
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- Aging Convergence Research Center > 1. Journal Articles
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