Genistein, a soy isoflavone, is a potent α-glucosidase inhibitor

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Title
Genistein, a soy isoflavone, is a potent α-glucosidase inhibitor
Author(s)
Dong Sun Lee; Sang Han Lee
Bibliographic Citation
FEBS Letters, vol. 501, no. 1, pp. 84-86
Publication Year
2001
Abstract
Genistein is an isoflavone that is known to be contained in soybean. It was proved that genistein plays a pivotal role in homeostasis in the human body. In the course of screening for useful α-glucosidase inhibitors, we isolated and identified genistein as a candidate for α-glucosidase inhibitor from fermentation broths of a Streptomyces sp. Genistein was shown to be a reversible, slow-binding, non-competitive inhibitor of yeast α-glucosidase with a Ki value of 5.7 × 10-8 M when the enzyme mixture was pretreated with genistein. These results show a possibility that genistein could be a useful tool for metabolic disorders.
Keyword
genisteinα-glucosidase inhibitorenzyme kinetics
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/S0014-5793(01)02631-X
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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