Identification of Streptomyces sp. AMLK-335 producing antibiotic substance inhibitory to vancomycin-resistant enterococci

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dc.contributor.authorKi Hyeong Rhee-
dc.contributor.authorKyung Hee Choi-
dc.contributor.authorChang Jin Kim-
dc.contributor.authorChang Han Kim-
dc.date.accessioned2017-04-19T08:58:20Z-
dc.date.available2017-04-19T08:58:20Z-
dc.date.issued2001-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5557-
dc.description.abstractThe actinomycete strain AMLK-335 was antagonistic to vancomycin-resistant enterococci (VRE). Based on the diaminopimelic acid (DAP) type, and morphological and physiological characteristics revealed by scanning electron microscopy (SEM), AMLK-335 was confirmed to belong to the genus Streptomyces. Analysis of the 16S rDNA nucleotide sequences found AMLK-335 to have a relationship with Streptomyces platensis. The production of antibiotic from this strain was most favorable when cultured on glucose, polypeptone, yeast extract (PY) medium for 6 days at 27 °C. The antibiotic was identified as cyclo(L-phenylalanyl-L-prolyl) by comparing it with the reported MS and NMR spectral data. Cyclo(phe-pro) from the PY cultures of AMLK-335 was most effective against the VRE strains E. faecium (K-98-637) and E. faecalis (K-98-258). Furthermore, cyclo(phe-pro) had antimicrobial activity against Bacillus subtilis, Microcuccs luteus, Staphylococcus aureus, and Saccharomyces cerevisiae, but it was ineffective against Candida albicans, Streptomyces murinus, and Aspergillus niger.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleIdentification of Streptomyces sp. AMLK-335 producing antibiotic substance inhibitory to vancomycin-resistant enterococci-
dc.title.alternativeIdentification of Streptomyces sp. AMLK-335 producing antibiotic substance inhibitory to vancomycin-resistant enterococci-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number3-
dc.citation.endPage474-
dc.citation.startPage469-
dc.citation.volume11-
dc.contributor.affiliatedAuthorChang Jin Kim-
dc.contributor.alternativeName이기형-
dc.contributor.alternativeName최경희-
dc.contributor.alternativeName김창진-
dc.contributor.alternativeName김창한-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 11, no. 3, pp. 469-474-
dc.subject.keywordvancomycin-resistant enterococci (VRE)-
dc.subject.keyword16S rDNA-
dc.subject.keywordstreptomyces sp. AMLK-335-
dc.subject.keywordcyclo (L-phenylalanyl-L-prolyl)-
dc.subject.localvancomycin-resistant enterococci (VRE)-
dc.subject.local16S rDNA-
dc.subject.local16s rDNA-
dc.subject.localstreptomyces sp. AMLK-335-
dc.subject.localcyclo (L-phenylalanyl-L-prolyl)-
dc.description.journalClassY-
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