Inhibitory activity for chitin synthase II from Saccharomyces cerevisiae by tannins and related compounds

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Title
Inhibitory activity for chitin synthase II from Saccharomyces cerevisiae by tannins and related compounds
Author(s)
Eui Il Hwang; Byung Tae Ahn; Hyang Bok Lee; Young Kook Kim; Kyong Soon Lee; Song Hae Bok; Young Tae Kim; Sung Uk Kim
Bibliographic Citation
Planta Medica, vol. 67, no. 6, pp. 501-504
Publication Year
2001
Abstract
In the course of search for potent inhibitors of chitin synthase II from natural resources, seven tannins and related compounds were isolated from the aerial part of Euphorbia pekinensis and identified as gallic acid, methyl gallate, 3-O-galloyl-(-)-shikimic acid, corilagin, geraniin, quercetin-3-O-(2″-O-galloyl)-β-D-glucoside, and kaempferol-3-O(2″-O-galloyl)-β-D-glucoside. These and nine related compounds, (-)-quinic acid, (-)-shikimic acid, ellagic acid, kaempferol, quercetin, quercitrin, rutin, quercetin-3-O-(2″-O-galloyl)-β-D-rutinoside and 1,3,4,6-tetra-O-galloyl-β-D-glucose, were evaluated for the inhibitory activity against chitin synthase II and III. They inhibited chitin synthase II with IC50 values of 18-206 μM, except for two organic acids, (-)-quinic acid and (-)-shikimic acid. Among them, 3-O-galloyl-(-)-shikimic acid was the most potent inhibitor against chitin synthase II of Saccharomyces cerevisiae with an IC50 value of 18 μM. The inhibition appears to be selective for chitin synthase II, as they did not appreciably inhibit chitin synthase III.
Keyword
Antifungal agentsChitin synthase IIChitin synthase III, chitin synthase II inhibitorEuphorbia pekinensisEuphorbiaceaeTannins
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2001-16487
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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