Hepatitis B virus X 형질전환 생쥐와 인체 간세포암종에서 proliferating cell nuclear antigen 발현과 자멸사

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dc.contributor.authorHyung Bae Moon-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorHyung Ryun Yoo-
dc.contributor.authorByung Joon So-
dc.contributor.authorKwon Mook Chae-
dc.contributor.authorHak Cheol Kim-
dc.contributor.authorKi Jung Yun-
dc.contributor.authorWon Cheol Han-
dc.contributor.authorHyang Jeong Jo-
dc.contributor.authorBo Yong Kim-
dc.date.accessioned2017-04-19T08:58:23Z-
dc.date.available2017-04-19T08:58:23Z-
dc.date.issued2001-
dc.identifier.issn17381843-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5580-
dc.description.abstractBackground : This experiment was designed to study the cell kinetics of hepatocellular carcinoma (HCC) in both hepatitis B virus X (HBx) transgenic mice and humans. Methods : The immunohistochemical stain of proliferating cell nuclear antigen (PCNA) and TdT-mediated dUTP-biotin nick end labeling (TUNEL) assay of apoptosis were used on formalin fixed-paraffin embedded tissues. Results : PCNA labeling indices (PCNA-LI) in the liver of HBx transgenic mice were markedly increased in HCC (11.3%) compare to the dysplastic areas (1.3%) and in the liver of non-transgenic littermates (0.1%). There was no significant difference of PCNA-LI in the dysplastic areas between HCC developed mice and non-HCC developed mice. Apoptosis labeling indices (Apoptosis-LI) in both the dysplastic areas and HCC of HBx transgenic mice were similar to those of non-transgenic littermates. PCNA-LI was markedly increased in human HCC (28.9%) compare to the background of HCC (2.9%) and the control liver (2.9%). Apoptosis-LI was decreased in human HCC (0.3%) compare to the background of HCC (0.4%) and the control liver (1.0%). Conclusion : There is a marked increase of cell proliferating activity in human HCC and in HCC of HBx transgenic mice, and there is a decrease of apoptosis in human HCC, but not in HCC of HBx transgenic mice.-
dc.publisherSouth Korea-
dc.titleHepatitis B virus X 형질전환 생쥐와 인체 간세포암종에서 proliferating cell nuclear antigen 발현과 자멸사-
dc.title.alternativeA study on the expression of proliferating cell nuclear antigen and apoptosis of the hepatocellular carcinoma in human and hepatitis B virus X transgenic mice-
dc.typeArticle-
dc.citation.titleKorean Journal of Pathology-
dc.citation.number2-
dc.citation.endPage136-
dc.citation.startPage129-
dc.citation.volume35-
dc.contributor.alternativeName문형배-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName유형륜-
dc.contributor.alternativeName소병준-
dc.contributor.alternativeName채권묵-
dc.contributor.alternativeName김학철-
dc.contributor.alternativeName윤기중-
dc.contributor.alternativeName한원철-
dc.contributor.alternativeName조향정-
dc.contributor.alternativeName김보용-
dc.identifier.bibliographicCitationKorean Journal of Pathology, vol. 35, no. 2, pp. 129-136-
dc.subject.keywordtransgenic-
dc.subject.keywordhepatocellular-
dc.subject.keywordcarcinoma-
dc.subject.keywordproliferating cell nuclear antigen-
dc.subject.keywordapoptosis-
dc.subject.localtransgenic-
dc.subject.localTransgenic-
dc.subject.localhepatocellular-
dc.subject.localHepatocellular-
dc.subject.localcarcinoma-
dc.subject.localCarcinoma-
dc.subject.localproliferating cell nuclear antigen-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.description.journalClassN-
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