DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyung Bae Moon | - |
dc.contributor.author | Dae Yeul Yu | - |
dc.contributor.author | Hyung Ryun Yoo | - |
dc.contributor.author | Byung Joon So | - |
dc.contributor.author | Kwon Mook Chae | - |
dc.contributor.author | Hak Cheol Kim | - |
dc.contributor.author | Ki Jung Yun | - |
dc.contributor.author | Won Cheol Han | - |
dc.contributor.author | Hyang Jeong Jo | - |
dc.contributor.author | Bo Yong Kim | - |
dc.date.accessioned | 2017-04-19T08:58:23Z | - |
dc.date.available | 2017-04-19T08:58:23Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5580 | - |
dc.description.abstract | Background : This experiment was designed to study the cell kinetics of hepatocellular carcinoma (HCC) in both hepatitis B virus X (HBx) transgenic mice and humans. Methods : The immunohistochemical stain of proliferating cell nuclear antigen (PCNA) and TdT-mediated dUTP-biotin nick end labeling (TUNEL) assay of apoptosis were used on formalin fixed-paraffin embedded tissues. Results : PCNA labeling indices (PCNA-LI) in the liver of HBx transgenic mice were markedly increased in HCC (11.3%) compare to the dysplastic areas (1.3%) and in the liver of non-transgenic littermates (0.1%). There was no significant difference of PCNA-LI in the dysplastic areas between HCC developed mice and non-HCC developed mice. Apoptosis labeling indices (Apoptosis-LI) in both the dysplastic areas and HCC of HBx transgenic mice were similar to those of non-transgenic littermates. PCNA-LI was markedly increased in human HCC (28.9%) compare to the background of HCC (2.9%) and the control liver (2.9%). Apoptosis-LI was decreased in human HCC (0.3%) compare to the background of HCC (0.4%) and the control liver (1.0%). Conclusion : There is a marked increase of cell proliferating activity in human HCC and in HCC of HBx transgenic mice, and there is a decrease of apoptosis in human HCC, but not in HCC of HBx transgenic mice. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Hepatitis B virus X 형질전환 생쥐와 인체 간세포암종에서 proliferating cell nuclear antigen 발현과 자멸사 | - |
dc.title.alternative | A study on the expression of proliferating cell nuclear antigen and apoptosis of the hepatocellular carcinoma in human and hepatitis B virus X transgenic mice | - |
dc.type | Article | - |
dc.citation.title | Korean Journal of Pathology | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 136 | - |
dc.citation.startPage | 129 | - |
dc.citation.volume | 35 | - |
dc.contributor.affiliatedAuthor | Dae Yeul Yu | - |
dc.contributor.alternativeName | 문형배 | - |
dc.contributor.alternativeName | 유대열 | - |
dc.contributor.alternativeName | 유형륜 | - |
dc.contributor.alternativeName | 소병준 | - |
dc.contributor.alternativeName | 채권묵 | - |
dc.contributor.alternativeName | 김학철 | - |
dc.contributor.alternativeName | 윤기중 | - |
dc.contributor.alternativeName | 한원철 | - |
dc.contributor.alternativeName | 조향정 | - |
dc.contributor.alternativeName | 김보용 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pathology, vol. 35, no. 2, pp. 129-136 | - |
dc.subject.keyword | transgenic | - |
dc.subject.keyword | hepatocellular | - |
dc.subject.keyword | carcinoma | - |
dc.subject.keyword | proliferating cell nuclear antigen | - |
dc.subject.keyword | apoptosis | - |
dc.subject.local | Transgenic | - |
dc.subject.local | transgenic | - |
dc.subject.local | Hepatocellular | - |
dc.subject.local | hepatocellular | - |
dc.subject.local | Carcinoma | - |
dc.subject.local | carcinoma | - |
dc.subject.local | proliferating cell nuclear antigen | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.description.journalClass | N | - |
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