Complestatin is a noncompetitive peptide antagonist of N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors : secure blockade of ischemic neuronal death

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dc.contributor.authorSo Young Seo-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorJun Sub Choi-
dc.contributor.authorChoun Ki Joo-
dc.contributor.authorSu Youne Chang-
dc.contributor.authorJun Mo Chung-
dc.contributor.authorSei Kwan Oh-
dc.contributor.authorByoung Joo Gwag-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T08:58:25Z-
dc.date.available2017-04-19T08:58:25Z-
dc.date.issued2001-
dc.identifier.issn0022-3565-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5589-
dc.description.abstractComplestatin, a peptide derived from Streptomyces, was found to protect cultured cortical neurons from excitotoxicity induced by N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or kainate. This neuroprotective behavior of complestatin was attributed to a blockade of Ca2+ ion entry and accumulation, after the activation of NMDA and AMPA/kainate receptors. Complestatin reversibly interfered with NMDA- and AMPA-mediated excitatory synaptic transmission. Complestatin also protected cortical neurons from prolonged deprivation of oxygen and glucose, more effectively than combined antagonists of NMDA and AMPA/kainate receptors. Neurotoxicity, evolving within 1 to 2 days after continuous exposure to combined NMDA and AMPA/kainate antagonists, was not observed in cortical cell cultures that were exposed to complestatin. Finally, complestatin dose dependently prevented neuronal death evolving within the inner nuclear and ganglion cell layers, after transient retinal ischemia. We conclude that complestatin possesses novel pharmacological properties that effectively prevent excitotoxicity under certain pathological conditions.-
dc.publisherAmer Soc Pharmacology Experimental Therapeutics-
dc.titleComplestatin is a noncompetitive peptide antagonist of N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors : secure blockade of ischemic neuronal death-
dc.title.alternativeComplestatin is a noncompetitive peptide antagonist of N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors : secure blockade of ischemic neuronal death-
dc.typeArticle-
dc.citation.titleJournal of Pharmacology and Experimental Therapeutics-
dc.citation.number1-
dc.citation.endPage384-
dc.citation.startPage377-
dc.citation.volume299-
dc.contributor.affiliatedAuthorBong Sik Yun-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorSei Kwan Oh-
dc.contributor.affiliatedAuthorIck Dong Yoo-
dc.contributor.alternativeName서소영-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName최준섭-
dc.contributor.alternativeName주춘기-
dc.contributor.alternativeName장수연-
dc.contributor.alternativeName정준모-
dc.contributor.alternativeName오세관-
dc.contributor.alternativeName곽병주-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Pharmacology and Experimental Therapeutics, vol. 299, no. 1, pp. 377-384-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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