DC Field | Value | Language |
---|---|---|
dc.contributor.author | Myung Sook Choi | - |
dc.contributor.author | Kyung Min Do | - |
dc.contributor.author | Yong Bok Park | - |
dc.contributor.author | Seon Min Jeon | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | Yeoun Kyung Lee | - |
dc.contributor.author | Mi Kyung Lee | - |
dc.contributor.author | Song Hae Bok | - |
dc.date.accessioned | 2017-04-19T08:58:26Z | - |
dc.date.available | 2017-04-19T08:58:26Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0250-6807 | - |
dc.identifier.uri | 10.1159/000046729 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5594 | - |
dc.description.abstract | Some bioflavonoids are potent antioxidants and have pharmacological effects similar to those of vitamin E. The interactive effect of naringin and vitamin E was studied with respect to cholesterol metabolism and antioxidant status. Naringin supplementation (0.1%, wt/wt) with comparable levels of vitamin E was given to rats with a high-cholesterol (1%, wt/wt) diet for 5 weeks. The amount of vitamin E included in naringin-free and naringin diets was a low (low-E) and a normal (normal-E) level. The naringin supplementation significantly lowered the concentrations of plasma cholesterol and triglyceride compared to the naringin-free group in low vitamin E-fed rats. HMG-CoA reductase activity was significantly lowered by naringin supplementation within both the low-vitamin E group (794.64 ± 9.87 vs. 432.18 ± 12.33 pmol/min/mg protein, mean ± SE; p < 0.05) and normal-vitamin E group (358.82 ± 11.4 vs. 218.22 ± 9.47 pmol/min/mg protein, mean ± SE; p < 0.05) compared to each of the naringin-free group. The HMG-CoA reductase activity was also significantly lowered by increased dietary vitamin E when compared within the naringin and naringin-free group, respectively. Neither dietary naringin nor vitamin E did significantly change the activities of hepatic antioxidant enzymes and plasma thiobarbituric acid-reactive substance level. These data indicate that naringin lowers the plasma lipid concentrations when the dietary vitamin E level is low. The HMG-CoA reductase-inhibitory effect of naringin was more potent when dietary vitamin E was at a normal level. These data may contribute to understanding the interactive effect of naringin and vitamin E on cholesterol biosynthesis in high-cholesterol-fed rats. | - |
dc.publisher | Karger | - |
dc.title | Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E | - |
dc.title.alternative | Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E | - |
dc.type | Article | - |
dc.citation.title | Annals of Nutrition and Metabolism | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 201 | - |
dc.citation.startPage | 193 | - |
dc.citation.volume | 45 | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.affiliatedAuthor | Song Hae Bok | - |
dc.contributor.alternativeName | 최명숙 | - |
dc.contributor.alternativeName | 도경민 | - |
dc.contributor.alternativeName | 박용복 | - |
dc.contributor.alternativeName | 전선민 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 이연경 | - |
dc.contributor.alternativeName | 이미경 | - |
dc.contributor.alternativeName | 복성해 | - |
dc.identifier.bibliographicCitation | Annals of Nutrition and Metabolism, vol. 45, no. 5, pp. 193-201 | - |
dc.identifier.doi | 10.1159/000046729 | - |
dc.subject.keyword | naringin | - |
dc.subject.keyword | vitamin E | - |
dc.subject.keyword | HMG-CoA reductase | - |
dc.subject.keyword | fecal sterols | - |
dc.subject.keyword | cholesterol metabolism | - |
dc.subject.keyword | antioxidative enzymes | - |
dc.subject.local | Naringin | - |
dc.subject.local | naringin | - |
dc.subject.local | Vitamin E | - |
dc.subject.local | vitamin E | - |
dc.subject.local | HMG-CoA reductase | - |
dc.subject.local | Fecal sterols | - |
dc.subject.local | fecal sterols | - |
dc.subject.local | cholesterol metabolism | - |
dc.subject.local | cholestorol metabolism | - |
dc.subject.local | Cholesterol metabolism | - |
dc.subject.local | antioxidative enzyme | - |
dc.subject.local | antioxidative enzymes | - |
dc.description.journalClass | Y | - |
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