Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E

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dc.contributor.authorMyung Sook Choi-
dc.contributor.authorKyung Min Do-
dc.contributor.authorYong Bok Park-
dc.contributor.authorSeon Min Jeon-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorYeoun Kyung Lee-
dc.contributor.authorMi Kyung Lee-
dc.contributor.authorSong Hae Bok-
dc.date.accessioned2017-04-19T08:58:26Z-
dc.date.available2017-04-19T08:58:26Z-
dc.date.issued2001-
dc.identifier.issn0250-6807-
dc.identifier.uri10.1159/000046729ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5594-
dc.description.abstractSome bioflavonoids are potent antioxidants and have pharmacological effects similar to those of vitamin E. The interactive effect of naringin and vitamin E was studied with respect to cholesterol metabolism and antioxidant status. Naringin supplementation (0.1%, wt/wt) with comparable levels of vitamin E was given to rats with a high-cholesterol (1%, wt/wt) diet for 5 weeks. The amount of vitamin E included in naringin-free and naringin diets was a low (low-E) and a normal (normal-E) level. The naringin supplementation significantly lowered the concentrations of plasma cholesterol and triglyceride compared to the naringin-free group in low vitamin E-fed rats. HMG-CoA reductase activity was significantly lowered by naringin supplementation within both the low-vitamin E group (794.64 ± 9.87 vs. 432.18 ± 12.33 pmol/min/mg protein, mean ± SE; p < 0.05) and normal-vitamin E group (358.82 ± 11.4 vs. 218.22 ± 9.47 pmol/min/mg protein, mean ± SE; p < 0.05) compared to each of the naringin-free group. The HMG-CoA reductase activity was also significantly lowered by increased dietary vitamin E when compared within the naringin and naringin-free group, respectively. Neither dietary naringin nor vitamin E did significantly change the activities of hepatic antioxidant enzymes and plasma thiobarbituric acid-reactive substance level. These data indicate that naringin lowers the plasma lipid concentrations when the dietary vitamin E level is low. The HMG-CoA reductase-inhibitory effect of naringin was more potent when dietary vitamin E was at a normal level. These data may contribute to understanding the interactive effect of naringin and vitamin E on cholesterol biosynthesis in high-cholesterol-fed rats.-
dc.publisherKarger-
dc.titleEffect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E-
dc.title.alternativeEffect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E-
dc.typeArticle-
dc.citation.titleAnnals of Nutrition and Metabolism-
dc.citation.number5-
dc.citation.endPage201-
dc.citation.startPage193-
dc.citation.volume45-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorSong Hae Bok-
dc.contributor.alternativeName최명숙-
dc.contributor.alternativeName도경민-
dc.contributor.alternativeName박용복-
dc.contributor.alternativeName전선민-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이연경-
dc.contributor.alternativeName이미경-
dc.contributor.alternativeName복성해-
dc.identifier.bibliographicCitationAnnals of Nutrition and Metabolism, vol. 45, no. 5, pp. 193-201-
dc.identifier.doi10.1159/000046729-
dc.subject.keywordnaringin-
dc.subject.keywordvitamin E-
dc.subject.keywordHMG-CoA reductase-
dc.subject.keywordfecal sterols-
dc.subject.keywordcholesterol metabolism-
dc.subject.keywordantioxidative enzymes-
dc.subject.localNaringin-
dc.subject.localnaringin-
dc.subject.localVitamin E-
dc.subject.localvitamin E-
dc.subject.localHMG-CoA reductase-
dc.subject.localFecal sterols-
dc.subject.localfecal sterols-
dc.subject.localcholesterol metabolism-
dc.subject.localcholestorol metabolism-
dc.subject.localCholesterol metabolism-
dc.subject.localantioxidative enzyme-
dc.subject.localantioxidative enzymes-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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