Typical demethylation events in cloned pig embryos : clues on specis-specific differnces in epigenetic reprogramming of a cloned donor genome

Cited 152 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorYong Kook Kang-
dc.contributor.authorDeog Bon Koo-
dc.contributor.authorJung Sun Park-
dc.contributor.authorYong Hee Choi-
dc.contributor.authorHa Na Kim-
dc.contributor.authorWon Kyong Chang-
dc.contributor.authorKyung Kwang Lee-
dc.contributor.authorYong Mahn Han-
dc.date.accessioned2017-04-19T08:58:28Z-
dc.date.available2017-04-19T08:58:28Z-
dc.date.issued2001-
dc.identifier.issn0021-9258-
dc.identifier.uri10.1074/jbc.M106516200ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5610-
dc.description.abstractWe investigated whether a genomic demethylation process occurs in pig preimplantation embryos produced by either normal fertilization or somatic cell nuclear transfer. The methylation status of the centromeric satellite and the PRE-1 short interspersed element (SINE) sequences was characterized using bisulfite-sequencing technology. Typical demethylation processes were identified in these repetitive sequences of the cloned donor genome during cleavage, the patterns of which were similar to the ones detected in fertilized counterparts. These findings are different from previous observations with cloned bovine embryos where various repeated regions of the donor genome exhibited aberrant methylation patterns. Our results indicate that species-specific differences exist in modifying the epigenetic status of cloned donor genomes.-
dc.publisherAmer Soc Biochemistry Molecular Biology Inc-
dc.titleTypical demethylation events in cloned pig embryos : clues on specis-specific differnces in epigenetic reprogramming of a cloned donor genome-
dc.title.alternativeTypical demethylation events in cloned pig embryos : clues on specis-specific differnces in epigenetic reprogramming of a cloned donor genome-
dc.typeArticle-
dc.citation.titleJournal of Biological Chemistry-
dc.citation.number43-
dc.citation.endPage39984-
dc.citation.startPage39980-
dc.citation.volume276-
dc.contributor.affiliatedAuthorYong Kook Kang-
dc.contributor.affiliatedAuthorDeog Bon Koo-
dc.contributor.affiliatedAuthorJung Sun Park-
dc.contributor.affiliatedAuthorKyung Kwang Lee-
dc.contributor.affiliatedAuthorYong Mahn Han-
dc.contributor.alternativeName강용국-
dc.contributor.alternativeName구덕본-
dc.contributor.alternativeName박정선-
dc.contributor.alternativeName최영희-
dc.contributor.alternativeName김하나-
dc.contributor.alternativeName장원경-
dc.contributor.alternativeName이경광-
dc.contributor.alternativeName한용만-
dc.identifier.bibliographicCitationJournal of Biological Chemistry, vol. 276, no. 43, pp. 39980-39984-
dc.identifier.doi10.1074/jbc.M106516200-
dc.description.journalClassY-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.