Nucleophilic substitution reactions of 4,5-dichloro-2-methyl-6-nitro-2H-pyridazin-3-one

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Title
Nucleophilic substitution reactions of 4,5-dichloro-2-methyl-6-nitro-2H-pyridazin-3-one
Author(s)
Kyu Tae Chang; Jeum Jong Kim; Young Kook Kim; Ho Yong Park; Byung Hwa Hyun; Motoo Shiro; Yong Jin Yoon; Woo Song Lee
Bibliographic Citation
Heterocycles, vol. 55, no. 10, pp. 1927-1935
Publication Year
2001
Abstract
4,5-Dichloro-2-methyl-6-nitro-2H-pyridazin-3-one (1) reacts with various substituted phenols and 2-mercaptopyrimidine in the presence of NaH or K2CO3 to give 3(2H)-pyridazinones (4, 5a-9a, 5b-9b, and 7c) in high yields. The regiochemistry was confirmed by X-Ray analysis and nOe experiments.
Keyword
N-acyclonucleosidephenoxylationpyridazineselectivity on pyridazine
ISSN
0385-5414
Publisher
Elsevier
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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