Absolute stereochemistry and solution conformation of promothiocins

Cited 10 time in scopus
Metadata Downloads
Title
Absolute stereochemistry and solution conformation of promothiocins
Author(s)
Bong Sik Yun; Ken-ichi Fujita; Kazuo Furihata; Haruo Seto
Bibliographic Citation
Tetrahedron, vol. 57, no. 48, pp. 9683-9687
Publication Year
2001
Abstract
Two members of thiopeptide class antibiotics, promothiocins A and B, were previously isolated from the mycelial extract of Streptomyces sp. SF2741 as tipA promoter inducing substances. Promothiocins are unique 26-membered thiopeptides composed of valine, 2-aminomethyl-5-methyloxazole-4-carboxylic acid, 2-(1-aminoethyl)thiazole-4-carboxylic acid, 2-(2-(1-aminoethyl)-5-methyloxazolyl)-3-(4-carboxythiazolyl)pyridine-6- carboxylic acid and dehydroalanine(s). The absolute stereochemistry and solution conformation of promothiocins have been investigated by a combination of the degradation works and molecular modeling experiments. These compounds contain characteristic dehydroalanine side chains in their structures that are closely related to promoter inducing activity, but are not essential.
Keyword
Absolute stereochemistryBiological activityConformationPromothiocins
ISSN
0040-4020
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0040-4020(01)00979-6
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.