Combretoxazolones : synthesis, cytotoxicity and antitumor activity
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- Title
- Combretoxazolones : synthesis, cytotoxicity and antitumor activity
- Author(s)
- Nguyen-Hai Nam; Yong Kim; Young Jae You; Dong Ho Hong; Hwan Mook Kim; Byung Zun Ahn
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 11, no. 23, pp. 3073-3076
- Publication Year
- 2001
- Abstract
- Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/S0960-894X(01)00622-9
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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