Enhanced IL-18 expression in common skin tumors

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dc.contributor.authorHyun Jeong Park-
dc.contributor.authorDae Yoo Byun-
dc.contributor.authorTae S Kim-
dc.contributor.authorYoung I Kim-
dc.contributor.authorJae S Kang-
dc.contributor.authorEun S Hahm-
dc.contributor.authorSeong H Kim-
dc.contributor.authorWang J Lee-
dc.contributor.authorHyun Keun Song-
dc.contributor.authorDo Young Yoon-
dc.contributor.authorChang J Kang-
dc.contributor.authorChnag Nam Lee-
dc.contributor.authorDong Houh-
dc.contributor.authorHyung Ok Kim-
dc.contributor.authorBaik Kee Cho-
dc.contributor.authorYoung Sill Kim-
dc.contributor.authorYool H Yang-
dc.contributor.authorKyung H Min-
dc.contributor.authorDae H Cho-
dc.date.accessioned2017-04-19T08:58:30Z-
dc.date.available2017-04-19T08:58:30Z-
dc.date.issued2001-
dc.identifier.issn01652478-
dc.identifier.uri10.1016/S0165-2478(01)00278-4ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5625-
dc.description.abstractInterleukin-18 (IL-18) has been found to have multiple effects upon various cells involved in inflammatory response. Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma. In this study, we investigated the pattern of IL-18 expression in the human system. IL-18 production was tested by enzyme linked immunosorbent assay (ELISA) assay in various tumor cell lines, including Raji (Burkett's lymphoma), IM-9 (B lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. Here, we report that enhanced IL-18 expression is positively correlated with malignant skin tumors such as SCC and melanoma, suggesting the importance role of IL-18 in malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in human skin tissue may provide an important clue to understand the pathogenesis of malignant skin tumors.-
dc.publisherElsevier-
dc.titleEnhanced IL-18 expression in common skin tumors-
dc.title.alternativeEnhanced IL-18 expression in common skin tumors-
dc.typeArticle-
dc.citation.titleImmunology Letters-
dc.citation.number3-
dc.citation.endPage219-
dc.citation.startPage215-
dc.citation.volume79-
dc.contributor.alternativeName박현정-
dc.contributor.alternativeName변대유-
dc.contributor.alternativeName김태-
dc.contributor.alternativeName김영-
dc.contributor.alternativeName강재-
dc.contributor.alternativeName함은-
dc.contributor.alternativeName김성-
dc.contributor.alternativeName이왕-
dc.contributor.alternativeName송현근-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName강창-
dc.contributor.alternativeName이창남-
dc.contributor.alternativeName허동-
dc.contributor.alternativeName김형옥-
dc.contributor.alternativeName조백기-
dc.contributor.alternativeName김영실-
dc.contributor.alternativeName양열-
dc.contributor.alternativeName민경-
dc.contributor.alternativeName조대호-
dc.identifier.bibliographicCitationImmunology Letters, vol. 79, no. 3, pp. 215-219-
dc.identifier.doi10.1016/S0165-2478(01)00278-4-
dc.subject.keywordIL-18-
dc.subject.keywordSkin tumors-
dc.subject.keywordSquamous cell carcinoma-
dc.subject.localIL-18-
dc.subject.localSkin tumors-
dc.subject.localSquamous cell carcinoma-
dc.description.journalClassY-
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