Genetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males

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dc.contributor.authorWon Ha Lee-
dc.contributor.authorTae Hong Hwang-
dc.contributor.authorGoo Taeg Oh-
dc.contributor.authorSung Uk Kwon-
dc.contributor.authorYoon Ho Choi-
dc.contributor.authorJeong Euy Park-
dc.date.accessioned2017-04-19T08:58:31Z-
dc.date.available2017-04-19T08:58:31Z-
dc.date.issued2001-
dc.identifier.issn1358-863X-
dc.identifier.uri10.1191/135886301680223635ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5635-
dc.description.abstractThe maintenance of balance between nitric oxide (NO) and the superoxide anion is required for proper functioning of the endothelium. To investigate the relationship between genetic factors associated with endothelial function and the development of coronary artery disease (CAD), endothelial nitric oxide synthase (ecNOS) gene a/b polymorphism and NADH/NADPH oxidase p22 phox gene C242T polymorphism were examined in 305 Korean male CAD patients and 215 healthy male control subjects. The β-fibrinogen gene H1/H2 polymorphism was also analyzed. Both ecNOS a/b and p22 phox C242T polymorphisms were found to be associated with the development of CAD in the study population (p = 0.020 and 0.011, respectively). When the association was analyzed by age, statistical significance was retained only in those <51 years (p = 0.021 and 0.025 for the a/b and the C242T polymorphism, respectively) and not in those >51 years of age (p = 0.155 and 0.278 respectively). However, the distribution of the β-fibrinogen H1/H2 genotypes was not found to be associated with the development of CAD in either the ≤50 (p = 0.611) or >50 groups (p = 0.188). The ecNOS gene a/b polymorphism and the NADH/NADPH oxidase p22 phox gene C242T polymorphism were found to be significantly associated with the development of CAD in Korean male patients less than 51 years old.-
dc.publisherSage-
dc.titleGenetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males-
dc.title.alternativeGenetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males-
dc.typeArticle-
dc.citation.titleVascular Medicine-
dc.citation.number2-
dc.citation.endPage108-
dc.citation.startPage103-
dc.citation.volume6-
dc.contributor.affiliatedAuthorGoo Taeg Oh-
dc.contributor.alternativeName이원하-
dc.contributor.alternativeName황태홍-
dc.contributor.alternativeName오구택-
dc.contributor.alternativeName권성욱-
dc.contributor.alternativeName최윤호-
dc.contributor.alternativeName박정의-
dc.identifier.bibliographicCitationVascular Medicine, vol. 6, no. 2, pp. 103-108-
dc.identifier.doi10.1191/135886301680223635-
dc.subject.keywordcoronary artery disease-
dc.subject.keywordendothelial dysfunction-
dc.subject.keywordnitric oxide-
dc.subject.localcoronary artery disease-
dc.subject.localCoronary artery disease-
dc.subject.localendothelial dysfunction-
dc.subject.localNO-
dc.subject.localnitric oxide-
dc.subject.localnitric oxide (NO)-
dc.subject.localNitric oxide-
dc.subject.localNO (Nitric oxide)-
dc.subject.localnitric oxide.-
dc.subject.localNitric oxid-
dc.subject.localNitric oxide (NO)-
dc.description.journalClassY-
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