Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

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Title
Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice
Author(s)
Joann P Palma; Hee Gu Lee; Mani Mohindru; Bong Su Kang; Mauro Dal Canto; Stephen D Miller; Byung S Kim
Bibliographic Citation
Journal of Neuroimmunology, vol. 116, no. 2, pp. 125-135
Publication Year
2001
Abstract
Theiler's virus induces immune-mediated demyelinating disease similar to human MS in susceptible mice. Though the MHC class II-restricted T cell response is critical, susceptibility/resistance is also associated with a MHC class I haplotype. Here we report that perforin-deficient C57BL/6 mice (pKO) are susceptible to demyelination and develop clinical disease. The levels of primary demyelination, proliferation, Th1 responses, and viral load were also markedly enhanced. In addition, immunization of pKO mice with UV-inactivated virus further enhanced clinical incidence and accelerated the disease course. Thus, perforin is most likely involved in viral clearance, hence protection from the disease.
Keyword
CTLinfectious immunityneuroimmunologyvirus
ISSN
0165-5728
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0165-5728(01)00293-4
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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