Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats

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Title
Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats
Author(s)
Jeong Sun Lee; Myung Sook Choi; Seon Min Jeon; Tae Sook Jeong; Yong Bok Park; Mi Kyung Lee; Song Hae Bok
Bibliographic Citation
Clinica Chimica Acta, vol. 314, no. 1, pp. 221-229
Publication Year
2001
Abstract
Background: Polyphenols appear to have antioxidant activities and may mediate lipid lowering. Methods: Four groups of rats, a high-cholesterol control (HC), HC + lovastatin, HC + 3,4-di(OH)-cinnamate, and HC + 3,4-di(OH)-hydrocinnamate, were given a semi-synthetic diet. The cinnamate derivative or lovastatin (0.1 g/100 g) supplements were given for 6 weeks. Results: The plasma total cholesterol concentration was significantly lowered by the 3,4-di(OH)-cinnamate supplement compared to the control or lovastatin group. The 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate supplements significantly lowered both the hepatic cholesterol and triglyceride levels, while lovastatin only lowered the hepatic cholesterol. The hepatic HMG-CoA reductase activities were significantly lower in the 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate groups than in the control or lovastatin group. The ACAT activity was only significantly lower in the lovastatin group compared to the other groups. With regards the hepatic antioxidant enzyme system, the CAT activity was significantly higher in the 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate groups compared to the control or lovastatin group. The two cinnamate derivatives resulted in an increased hepatic GSH-Px activity. Meanwhile, all the supplements significantly lowered the hepatic thiobarbituric acid reactive substances (TBARS) content. However, the 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate supplements did not alter the neutral sterol and total fecal sterol. Conclusions: Both cinnamate derivatives were potent in lipid-lowering and altering the antioxidative enzyme. Furthermore, these results also suggest that 3,4-di(OH)-cinnamate is more effective than 3,4-di(OH)-hydrocinnamate in its lipid-lowering action.
Keyword
3,4-di(OH)-cinnamate3,4-di(OH)-hydrocinnamateAntioxidant enzymesCholesterol metabolismFecal sterolsHMG-CoA reductase
ISSN
0009-8981
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0009-8981(01)00700-8
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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