Rutaecarpine, a quinazolinocarboline alkaloid, inhibits prostaglandin production in RAW264.7 macrophages

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dc.contributor.authorHyun Goo Woo-
dc.contributor.authorChang Hoon Lee-
dc.contributor.authorMin Soo Noh-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorYi Sook Jung-
dc.contributor.authorEun Joo Baik-
dc.contributor.authorChang Hyun Moon-
dc.contributor.authorSoo Hwan Lee-
dc.date.accessioned2017-04-19T08:58:33Z-
dc.date.available2017-04-19T08:58:33Z-
dc.date.issued2001-
dc.identifier.issn0032-0943-
dc.identifier.uri10.1055/s-2001-16479ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5648-
dc.description.abstractIn order to delineate the mechanism involved in the anti-inflammatory activity of rutaecarpine, its effects on the production of prostaglandin (PG) and therein involved enzymes were examined. Rutaecarpine reduced the production of PGE2 in RAW264.7 cells treated with lipopolysaccharide (LPS) in a dose dependent manner when added to the culture media at the time of stimulation. However, the inhibition of total cellular cyclooxygenase (COX) activity under the same experimental condition was observed only at high concentrations of rutaecarpine. Rutaecarpine did not affected the levels of COX-2 mRNA and protein in macrophages stimulated with LPS. Calcium ionophore A23187 induced-PG production and [3H]-arachidonic acid release were significantly decreased by the pretreatment of rutaecarpine for 30 minutes. With the same treatment schedule, however, rutaecarpine failed to alter the activities of cellular COX-1 and COX-2. Collectively, our data suggest that anti-inflammatory effect of rutaecarpine is, at least in part, ascribed to the diminution of PG production through inhibition of arachidonic acid release albeit the nature of its effects on PLA2 activity remains to be elaborated.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleRutaecarpine, a quinazolinocarboline alkaloid, inhibits prostaglandin production in RAW264.7 macrophages-
dc.title.alternativeRutaecarpine, a quinazolinocarboline alkaloid, inhibits prostaglandin production in RAW264.7 macrophages-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number6-
dc.citation.endPage509-
dc.citation.startPage505-
dc.citation.volume67-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeName우현구-
dc.contributor.alternativeName이창훈-
dc.contributor.alternativeName노민수-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName정이숙-
dc.contributor.alternativeName백은주-
dc.contributor.alternativeName문창현-
dc.contributor.alternativeName이수환-
dc.identifier.bibliographicCitationPlanta Medica, vol. 67, no. 6, pp. 505-509-
dc.identifier.doi10.1055/s-2001-16479-
dc.subject.keywordcyclooxygenase-
dc.subject.keywordevodia rutaecarpa-
dc.subject.keywordphospholipase A2-
dc.subject.keywordprostaglandin-
dc.subject.keywordrutaceae-
dc.subject.keywordrutaecarpine-
dc.subject.localCyclo-oxygenase-
dc.subject.localCyclooxygenase-
dc.subject.localCyclooxygenases-
dc.subject.localcyclooxygenase-
dc.subject.localEvodia rutaecarpa-
dc.subject.localevodia rutaecarpa-
dc.subject.localPhospholipase A2-
dc.subject.localPhospholipase A2 (PLA2)-
dc.subject.localPhospholipase A₂(PLA₂)-
dc.subject.localphospholipase A2-
dc.subject.localphospholipase A₂-
dc.subject.localProstaglandins-
dc.subject.localprostaglandin-
dc.subject.localRutaceae-
dc.subject.localrutaceae-
dc.subject.localRutaecarpine-
dc.subject.localrutaecarpine-
dc.description.journalClassY-
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