Targeted gene disruption of the avermectin B O-methyltransferase gene in Streptomyces avermitilis

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Title
Targeted gene disruption of the avermectin B O-methyltransferase gene in Streptomyces avermitilis
Author(s)
Young Soo Hong; Jeong Hyung Lee; Hang Sub Kim; Kyu Won Kim; Jung Joon Lee
Bibliographic Citation
Biotechnology Letters, vol. 23, no. 21, pp. 1765-1770
Publication Year
2001
Abstract
The biological activity of avermectin B components is superior to that of avermectin A components, which are derived from avermectin B by avermectin B 5-O-methyltransferase. Gene disruption, targeting avermectin B 5-O-methyltransferase gene in Streptomyces avermitilis, was carried out to obtain a strain of avermectin B producer. Phenotype analysis of the mutant with the disrupted O-methyltransferase gene showed that only avermectin B components were produced with a significant increase in production.
Keyword
avermectinavermectin O-methyltransferasegene disruption
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1012496317299
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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