Molecular cloning and characterization of the doxA cytochrome P-450 hydroxylase gene in Streptomyces peucetius subsp. caesius ATCC 27952

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Title
Molecular cloning and characterization of the doxA cytochrome P-450 hydroxylase gene in Streptomyces peucetius subsp. caesius ATCC 27952
Author(s)
Young Soo Hong; Hang Sub Kim; Jeong Hyung Lee; Kyu Won Kim; Jung Joon Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 11, no. 5, pp. 895-898
Publication Year
2001
Abstract
DNA sequence analysis of doxA from Streptomyces peucetius subsp. caesius ATCC 27952 revealed a 95% amino acid identity with that of Streptomyces strain C5. DoxA from S. peucetius subsp. caesius ATCC 27952 encodes a peptide with both conserved heme-binding and dioxygen-binding motifs. Expression of this gene in S. lividans 1326 resulted in bioconversion of daunorubicin to doxorubicin.
Keyword
cytochrome P-450DoxAhydroxylasestreptomyces peucetius subspcytochrome P450caesius
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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