Molecular cloning and characterization of the doxA cytochrome P-450 hydroxylase gene in Streptomyces peucetius subsp. caesius ATCC 27952
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- Title
- Molecular cloning and characterization of the doxA cytochrome P-450 hydroxylase gene in Streptomyces peucetius subsp. caesius ATCC 27952
- Author(s)
- Young Soo Hong; Hang Sub Kim; Jeong Hyung Lee; Kyu Won Kim; Jung Joon Lee
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 11, no. 5, pp. 895-898
- Publication Year
- 2001
- Abstract
- DNA sequence analysis of doxA from Streptomyces peucetius subsp. caesius ATCC 27952 revealed a 95% amino acid identity with that of Streptomyces strain C5. DoxA from S. peucetius subsp. caesius ATCC 27952 encodes a peptide with both conserved heme-binding and dioxygen-binding motifs. Expression of this gene in S. lividans 1326 resulted in bioconversion of daunorubicin to doxorubicin.
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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