Anti-angiogenic activities of gliotoxin and its methylthioderivative, fungal metabolites

Cited 35 time in scopus
Metadata Downloads
Title
Anti-angiogenic activities of gliotoxin and its methylthioderivative, fungal metabolites
Author(s)
Hee Jung Lee; Jeong Hyung Lee; Bang Yeon Hwang; Hang Sub Kim; Jung Joon Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 24, no. 5, pp. 397-401
Publication Year
2001
Abstract
In the search for new naturally occurring angiogenic inhibitor, we found that culture broths from two unidentified fungal strains exerted potent inhibitory activities on capillary-like tube formation of human umbilical vein endothelial cells (HUVEC) in vitro. Two active compounds were isolated by bioassay-guided separation and their structures were identified as gliotoxin (1) and its derivative methylthiogliotoxin (2) by spectroscopic analyses. These compounds significantly inhibited the migration of HUVEC assessed by in vitro wounding migration assay and exhibited at least 10 times more potent inhibition of proliferation of HUVECs as compared with that of cancer cell lines such as HeLa, MCF-7, and KB 3-1 cells. Especially, gliotoxin having disulfide group exerted more potent activities than methylthiogliotoxin, suggesting that gliotoxin could be a useful compound for further study as an anti-angiogenic agent.
Keyword
anti-angiogenic activitycytotoxicitygliotoxinhuvecs. wound migrationmethylthiogliotoxin
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02975182
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.