Pleckstrin homology domain interacts with Rkp1/Cpc2, a RACK1 homolog, to modulate Pck2-mediated signaling process in Schizosaccharomyces pombe

Cited 3 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorMi Sun Won-
dc.contributor.authorYoung Joo Jang-
dc.contributor.authorKyung Sook Chung-
dc.contributor.authorDong Uk Kim-
dc.contributor.authorKwang Lae Hoe-
dc.contributor.authorMi Young Han-
dc.contributor.authorHyung Bae Kim-
dc.contributor.authorSang Hee Lee-
dc.contributor.authorHyun Wha Oh-
dc.contributor.authorHyang Sook Yoo-
dc.date.accessioned2017-04-19T08:58:37Z-
dc.date.available2017-04-19T08:58:37Z-
dc.date.issued2001-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1006/bbrc.2001.6094ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5671-
dc.description.abstractRkp1/Cpc2, a fission yeast RACK1 homolog, interacts with Pck2, a PKC homolog, and is involved in the regulation of pck2-mediated signaling process. The N-terminal region of split pleckstrin homology domain (nPH) in human PLC-γ1 bound to Rkp1/Cpc2 concomitantly with Pck2. nPH inhibited kinase activity of GST-Pck2 purified from Schizosaccharomyces pombe in vitro. The lethality induced by pck2+ overexpression was suppressed by coexpression of either rkp1+ or nPH domain. This result suggests that Rkp1/Cpc2 interacts with PH domain-containing protein and regulates the Pck2-mediated signaling process in S. pombe.-
dc.publisherElsevier-
dc.titlePleckstrin homology domain interacts with Rkp1/Cpc2, a RACK1 homolog, to modulate Pck2-mediated signaling process in Schizosaccharomyces pombe-
dc.title.alternativePleckstrin homology domain interacts with Rkp1/Cpc2, a RACK1 homolog, to modulate Pck2-mediated signaling process in Schizosaccharomyces pombe-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number5-
dc.citation.endPage992-
dc.citation.startPage987-
dc.citation.volume289-
dc.contributor.affiliatedAuthorMi Sun Won-
dc.contributor.affiliatedAuthorYoung Joo Jang-
dc.contributor.affiliatedAuthorKyung Sook Chung-
dc.contributor.affiliatedAuthorDong Uk Kim-
dc.contributor.affiliatedAuthorKwang Lae Hoe-
dc.contributor.affiliatedAuthorMi Young Han-
dc.contributor.affiliatedAuthorSang Hee Lee-
dc.contributor.affiliatedAuthorHyun Wha Oh-
dc.contributor.affiliatedAuthorHyang Sook Yoo-
dc.contributor.alternativeName원미선-
dc.contributor.alternativeName장영주-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeName허광래-
dc.contributor.alternativeName한미영-
dc.contributor.alternativeName김형배-
dc.contributor.alternativeName이상희-
dc.contributor.alternativeName오현화-
dc.contributor.alternativeName유향숙-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 289, no. 5, pp. 987-992-
dc.identifier.doi10.1006/bbrc.2001.6094-
dc.subject.keywordFission yeast-
dc.subject.keywordPleckstrin homology domain-
dc.subject.keywordRACK1-
dc.subject.keywordRkp1/Cpc2-
dc.subject.localFission yeast-
dc.subject.localfission yeast-
dc.subject.localPleckstrin Homology (PH) domain-
dc.subject.localPleckstrin homology domain-
dc.subject.localRACK1-
dc.subject.localRkp1/Cpc2-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Research on National Challenges > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.