5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium

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Title
5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium
Author(s)
Kwang Hee Son; Ju Young Kwon; Ha Won Jeong; Hyae Kyeong Kim; Chang Jin Kim; Yi Hwa Chang; Jung Do Choi; Byoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 10, no. 1, pp. 185-188
Publication Year
2002
Abstract
5-Demethylovalicin, isolated from the fermentation broth Chrysosporium inhibited the recombinant human MetAP-2 (IC50=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC50=100 nM) in cell proliferation assay without cytotoxicity on the transformed cell lines.
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0968-0896(01)00268-1
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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