DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kyu Hwan Park | - |
dc.contributor.author | Jae Eun Suk | - |
dc.contributor.author | Richard Jacobsen | - |
dc.contributor.author | William R Gray | - |
dc.contributor.author | J Michael McIntosh | - |
dc.contributor.author | Kyou Hoon Han | - |
dc.date.accessioned | 2017-04-19T08:58:39Z | - |
dc.date.available | 2017-04-19T08:58:39Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | 10.1074/jbc.M107798200 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5689 | - |
dc.description.abstract | A high resolution structure of α-conotoxin EI has been determined by 1H NMR spectroscopy and molecular modeling. α-Conotoxin EI has the same disulfide framework as α4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the neuromuscular receptor as do the α3/5 and αA conotoxins. The unique binding preference of α-conotoxin EI to the α1/δ subunit interface of Torpedo neuromuscular receptor makes it a valuable structural template for superposition of various α-conotoxins possessing distinct receptor subtype specificities. Structural comparison of α-conotoxin EI with the γ-subunit favoring α-conotoxin GI suggests that the Torpedo α-subunit preference of the former originates from its second loop. Superposition of three-dimensional structures of seven α-conotoxins reveals that the estimated size of the toxin-binding pocket in nicotinic acetylcholine receptor is ∼20 ? (height) × 20 ? (width) × 15 ? (thickness). | - |
dc.publisher | Elsevier | - |
dc.title | Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the α₁/δ subunit interface of Torpedo nicotinic acetylcholine receptor | - |
dc.title.alternative | Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the α₁/δ subunit interface of Torpedo nicotinic acetylcholine receptor | - |
dc.type | Article | - |
dc.citation.title | Journal of Biological Chemistry | - |
dc.citation.number | 52 | - |
dc.citation.endPage | 49033 | - |
dc.citation.startPage | 49028 | - |
dc.citation.volume | 276 | - |
dc.contributor.affiliatedAuthor | Kyu Hwan Park | - |
dc.contributor.affiliatedAuthor | Jae Eun Suk | - |
dc.contributor.affiliatedAuthor | Kyou Hoon Han | - |
dc.contributor.alternativeName | 박규환 | - |
dc.contributor.alternativeName | 석재은 | - |
dc.contributor.alternativeName | Jacobsen | - |
dc.contributor.alternativeName | Gray | - |
dc.contributor.alternativeName | McIntosh | - |
dc.contributor.alternativeName | 한규훈 | - |
dc.identifier.bibliographicCitation | Journal of Biological Chemistry, vol. 276, no. 52, pp. 49028-49033 | - |
dc.identifier.doi | 10.1074/jbc.M107798200 | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.