Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the α₁/δ subunit interface of Torpedo nicotinic acetylcholine receptor

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dc.contributor.authorKyu Hwan Park-
dc.contributor.authorJae Eun Suk-
dc.contributor.authorRichard Jacobsen-
dc.contributor.authorWilliam R Gray-
dc.contributor.authorJ Michael McIntosh-
dc.contributor.authorKyou Hoon Han-
dc.date.accessioned2017-04-19T08:58:39Z-
dc.date.available2017-04-19T08:58:39Z-
dc.date.issued2001-
dc.identifier.issn0021-9258-
dc.identifier.uri10.1074/jbc.M107798200ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5689-
dc.description.abstractA high resolution structure of α-conotoxin EI has been determined by 1H NMR spectroscopy and molecular modeling. α-Conotoxin EI has the same disulfide framework as α4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the neuromuscular receptor as do the α3/5 and αA conotoxins. The unique binding preference of α-conotoxin EI to the α1/δ subunit interface of Torpedo neuromuscular receptor makes it a valuable structural template for superposition of various α-conotoxins possessing distinct receptor subtype specificities. Structural comparison of α-conotoxin EI with the γ-subunit favoring α-conotoxin GI suggests that the Torpedo α-subunit preference of the former originates from its second loop. Superposition of three-dimensional structures of seven α-conotoxins reveals that the estimated size of the toxin-binding pocket in nicotinic acetylcholine receptor is ∼20 ? (height) × 20 ? (width) × 15 ? (thickness).-
dc.publisherElsevier-
dc.titleSolution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the α₁/δ subunit interface of Torpedo nicotinic acetylcholine receptor-
dc.title.alternativeSolution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the α₁/δ subunit interface of Torpedo nicotinic acetylcholine receptor-
dc.typeArticle-
dc.citation.titleJournal of Biological Chemistry-
dc.citation.number52-
dc.citation.endPage49033-
dc.citation.startPage49028-
dc.citation.volume276-
dc.contributor.affiliatedAuthorKyu Hwan Park-
dc.contributor.affiliatedAuthorJae Eun Suk-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName박규환-
dc.contributor.alternativeName석재은-
dc.contributor.alternativeNameJacobsen-
dc.contributor.alternativeNameGray-
dc.contributor.alternativeNameMcIntosh-
dc.contributor.alternativeName한규훈-
dc.identifier.bibliographicCitationJournal of Biological Chemistry, vol. 276, no. 52, pp. 49028-49033-
dc.identifier.doi10.1074/jbc.M107798200-
dc.description.journalClassY-
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