Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity I : fermentation, isolation, physico-chemical properties and biological activity

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Title
Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity I : fermentation, isolation, physico-chemical properties and biological activity
Author(s)
Hiroyuki Kobayashi; Kazuo Shin-ya; Koji Nagai; Ken-ichi Suzuki; Yoichi Hayakawa; Haruo Seto; Bong Sik Yun; In Ja Ryoo; Jung Sik Kim; Chang Jin Kim; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 54, no. 12, pp. 1013-1018
Publication Year
2001
Abstract
Glutamate, an excitatory amino acid, is known to induce neurotoxicity in central nervous system under abnormal conditions such as ischemia, hypoglycemia, epilepsy, Huntington's chorea, Parkinson's disease and Alzheimer's disease. In our search for neuroprotective agents of microbial origin against excitatory neurotoxins, we have isolated two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound complestatin, from the fermentation broth of Streptomyces sp. Q27107. Neuroprotectins protected primary cultured chick telencephalic neurons from glutamate- and kainate-induced excitotoxicities in a dose-dependant fashion.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.54.1013
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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