Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neurons from excitotoxicity II : strucutre determination

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Title
Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neurons from excitotoxicity II : strucutre determination
Author(s)
Hiroyuki Kobayashi; Kazuo Shin-ya; Kazuo Furihata; Koji Nagai; Ken-ichi Suzuki; Yoichi Hayakawa; Haruo Seto; Bong Sik Yun; In Ja Ryoo; Jung Sik Kim; Chang Jin Kim; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 54, no. 12, pp. 1019-1024
Publication Year
2001
Abstract
In the course of our search for neuroprotective agents of microbial origin against kainate-induced neurotoxicity, we have succeeded in the isolation of two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound, complestatin, from the fermentation broth of Streptomyces sp. Q27107. They are closely related in structure to complestatin and possess an oxindolylalanine moiety in place of the tryptophan residue present in complestatin.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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