The expression of bok is regulated by serum in HC11 mammary epithelial cells

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Title
The expression of bok is regulated by serum in HC11 mammary epithelial cells
Author(s)
Seok Ho Ha; Sul Ra Lee; Tae Hoon Lee; Young Min Kim; Myung Gi Baik; Yun Jaie Choi
Bibliographic Citation
Molecules and Cells, vol. 12, no. 3, pp. 368-371
Publication Year
2001
Abstract
Epithelial cells within the mammary gland undergo apoptosis during weaning. To determine the expression of Bok mRNA (a member of the pro-apoptotic Bcl-2 family) in the mammary gland and its regulation, we examined the expression of the Bok transcript in the mouse mammary gland and HC11 mammary epithelial cells in culture through RT-PCR. The Bok mRNA expression was found in the mammary gland. The expression of the Bok mRNA level was induced through serum starvation and overexpression of Bok induced apoptosis in HC11 cells in culture. These results indicate that the expression of Bok mRNA in the mammary gland is regulated through serum starvation. It also may be related to the mammary involution.
Keyword
ApoptosisBokHC11 Mammary Epithelial CellsSerum Starvation
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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