Citrinin hydrate inhibits serotonin N-acetyltransferase catalyzing the conversion of serotonin to N-acetylserotonin

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dc.contributor.authorIn Kyoung Lee-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorKyong Tai Kim-
dc.contributor.authorBo Hwa Choi-
dc.contributor.authorTae Ju Park-
dc.contributor.authorYoung Ho Kim-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T08:58:45Z-
dc.date.available2017-04-19T08:58:45Z-
dc.date.issued2001-
dc.identifier.issn10177825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5723-
dc.description.abstractIn an attempt to search for serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) inhibitors from microbial metabolites, we found the culture broth of Penicillium sp. 80722 which showed a strong inhibitory activity against AA-NAT. The active principle has been identified as citrinin hydrate through bioassay-guided fractionation of cultural broth, and structure elucidation derived by spectroscopic analyses. Citrinin hydrate inhibits AA-NAT with an IC50 value of 173 μM in a dose-dependent manner. Although citrinin hydrate was previously isolated as human rhinovirus 3C-protease inhibitor, this was recognized as the first AA-NAT inhibitor isolated from natural sources.-
dc.publisherSouth Korea-
dc.titleCitrinin hydrate inhibits serotonin N-acetyltransferase catalyzing the conversion of serotonin to N-acetylserotonin-
dc.title.alternativeCitrinin hydrate inhibits serotonin N-acetyltransferase catalyzing the conversion of serotonin to N-acetylserotonin-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number6-
dc.citation.endPage1101-
dc.citation.startPage1099-
dc.citation.volume11-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName김경태-
dc.contributor.alternativeName최보화-
dc.contributor.alternativeName박태주-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 11, no. 6, pp. 1099-1101-
dc.subject.keywordcitrinin hydrate-
dc.subject.keywordpenicillium sp.-
dc.subject.keywordserotonin n-acetyltransferase (AA-NAT) inhibitor-
dc.subject.localcitrinin hydrate-
dc.subject.localpenicillium sp.-
dc.subject.localPenicillium sp.-
dc.subject.localserotonin n-acetyltransferase (AA-NAT) inhibitor-
dc.description.journalClassY-
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