Anticomplement activity of terpenoids from the spores of Ganoderma lucidum

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dc.contributor.authorByung Sun Min-
dc.contributor.authorJiang Jing Gao-
dc.contributor.authorMasao Hattori-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorYoung Ho Kim-
dc.date.accessioned2017-04-19T08:58:48Z-
dc.date.available2017-04-19T08:58:48Z-
dc.date.issued2001-
dc.identifier.issn0032-0943-
dc.identifier.uri10.1055/s-2001-18854ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5740-
dc.description.abstractA new lanostane-type terpenoid, lucidenic acid SP1 (1), was isolated from a CHCl3-soluble fraction of Ganoderma lucidum spores together with four other known compounds (2-5). The structure of lucidenic acid SP1 was determined to be 3β,7β-dihydroxy-4,4,14α-trimethyl-11,15-dioxo-5α-chol- 8-en-24-oic acid by spectroscopic means including 2D-NMR. Twelve triterpenes (1-12) isolated from G. lucidum spores were investigated in vitro for their anticomplementary activity. Compounds 1-5 were inactive, whereas ganoderiol F (8), ganodermanondiol (9) and ganodermanontriol (10) showed a strong anticomplement activity against the classical pathway (CP) of the complement system with IC50 values of 4.8, 41.7, and 17.2 μM, respectively. The potency of these triterpene alcohols (8-10) in inhibiting CP activity was improved when the number of hydroxymethyl groups on the side chain moiety is increased. On the other hand, the ganoderic acids 1-7, which contain a carboxyl group in the side chain, and lucidumols A and B (11, 12) had little activity on this system.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleAnticomplement activity of terpenoids from the spores of Ganoderma lucidum-
dc.title.alternativeAnticomplement activity of terpenoids from the spores of Ganoderma lucidum-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number9-
dc.citation.endPage814-
dc.citation.startPage811-
dc.citation.volume67-
dc.contributor.affiliatedAuthorByung Sun Min-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeNameGao-
dc.contributor.alternativeNameHattori-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName김영호-
dc.identifier.bibliographicCitationPlanta Medica, vol. 67, no. 9, pp. 811-814-
dc.identifier.doi10.1055/s-2001-18854-
dc.subject.keywordAnticomplementary activity-
dc.subject.keywordGanoderiol F-
dc.subject.keywordGanoderma lucidum-
dc.subject.keywordLanostane-type triterpene-
dc.subject.keywordLucidenic acid SP1-
dc.subject.keywordPolyporaceae-
dc.subject.localanticomplementary actvity-
dc.subject.localAnticomplementary activity-
dc.subject.localAnti-complementary activity-
dc.subject.localanti-complementary activity-
dc.subject.localanticomplementary activity-
dc.subject.localGanoderiol F-
dc.subject.localGanoderma lucidum-
dc.subject.localganoderma lucidum-
dc.subject.localLanostane-type triterpene-
dc.subject.localLucidenic acid SP1-
dc.subject.localPolyporaceae-
dc.subject.localpolyporaceae-
dc.description.journalClassY-
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