DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byung Sun Min | - |
dc.contributor.author | Jiang Jing Gao | - |
dc.contributor.author | Masao Hattori | - |
dc.contributor.author | Hyeong Kyu Lee | - |
dc.contributor.author | Young Ho Kim | - |
dc.date.accessioned | 2017-04-19T08:58:48Z | - |
dc.date.available | 2017-04-19T08:58:48Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | 10.1055/s-2001-18854 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5740 | - |
dc.description.abstract | A new lanostane-type terpenoid, lucidenic acid SP1 (1), was isolated from a CHCl3-soluble fraction of Ganoderma lucidum spores together with four other known compounds (2-5). The structure of lucidenic acid SP1 was determined to be 3β,7β-dihydroxy-4,4,14α-trimethyl-11,15-dioxo-5α-chol- 8-en-24-oic acid by spectroscopic means including 2D-NMR. Twelve triterpenes (1-12) isolated from G. lucidum spores were investigated in vitro for their anticomplementary activity. Compounds 1-5 were inactive, whereas ganoderiol F (8), ganodermanondiol (9) and ganodermanontriol (10) showed a strong anticomplement activity against the classical pathway (CP) of the complement system with IC50 values of 4.8, 41.7, and 17.2 μM, respectively. The potency of these triterpene alcohols (8-10) in inhibiting CP activity was improved when the number of hydroxymethyl groups on the side chain moiety is increased. On the other hand, the ganoderic acids 1-7, which contain a carboxyl group in the side chain, and lucidumols A and B (11, 12) had little activity on this system. | - |
dc.publisher | Georg Thieme Verlag Kg | - |
dc.title | Anticomplement activity of terpenoids from the spores of Ganoderma lucidum | - |
dc.title.alternative | Anticomplement activity of terpenoids from the spores of Ganoderma lucidum | - |
dc.type | Article | - |
dc.citation.title | Planta Medica | - |
dc.citation.number | 9 | - |
dc.citation.endPage | 814 | - |
dc.citation.startPage | 811 | - |
dc.citation.volume | 67 | - |
dc.contributor.affiliatedAuthor | Byung Sun Min | - |
dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
dc.contributor.alternativeName | 민병선 | - |
dc.contributor.alternativeName | Gao | - |
dc.contributor.alternativeName | Hattori | - |
dc.contributor.alternativeName | 이형규 | - |
dc.contributor.alternativeName | 김영호 | - |
dc.identifier.bibliographicCitation | Planta Medica, vol. 67, no. 9, pp. 811-814 | - |
dc.identifier.doi | 10.1055/s-2001-18854 | - |
dc.subject.keyword | Anticomplementary activity | - |
dc.subject.keyword | Ganoderiol F | - |
dc.subject.keyword | Ganoderma lucidum | - |
dc.subject.keyword | Lanostane-type triterpene | - |
dc.subject.keyword | Lucidenic acid SP1 | - |
dc.subject.keyword | Polyporaceae | - |
dc.subject.local | anticomplementary actvity | - |
dc.subject.local | Anticomplementary activity | - |
dc.subject.local | Anti-complementary activity | - |
dc.subject.local | anti-complementary activity | - |
dc.subject.local | anticomplementary activity | - |
dc.subject.local | Ganoderiol F | - |
dc.subject.local | Ganoderma lucidum | - |
dc.subject.local | ganoderma lucidum | - |
dc.subject.local | Lanostane-type triterpene | - |
dc.subject.local | Lucidenic acid SP1 | - |
dc.subject.local | Polyporaceae | - |
dc.subject.local | polyporaceae | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.