Cytotoxic triterpenoides from Alismatis Rhizoma
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- Title
- Cytotoxic triterpenoides from Alismatis Rhizoma
- Author(s)
- Sang Myung Lee; Yung Hee Kho; Byung Sun Min; Jin Hee Kim; Min Kyun Na; Shin Jyung Kang; Hack Young Maeng; Ki Hwan Bae
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 24, no. 6, pp. 524-526
- Publication Year
- 2001
- Abstract
- Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 μg/ml, respectively.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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