Cytotoxic triterpenoides from Alismatis Rhizoma

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Title
Cytotoxic triterpenoides from Alismatis Rhizoma
Author(s)
Sang Myung Lee; Yung Hee Kho; Byung Sun Min; Jin Hee Kim; Min Kyun Na; Shin Jyung Kang; Hack Young Maeng; Ki Hwan Bae
Bibliographic Citation
Archives of Pharmacal Research, vol. 24, no. 6, pp. 524-526
Publication Year
2001
Abstract
Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 μg/ml, respectively.
Keyword
alismatis rhizomaalisol bcytotoxicity
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02975158
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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