Oxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cells

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dc.contributor.authorJae Ryong kim-
dc.contributor.authorKi Sun Kwon-
dc.contributor.authorHae Won Yoon-
dc.contributor.authorSeung Rock Lee-
dc.contributor.authorSue Goo Rhee-
dc.date.accessioned2017-04-19T08:58:51Z-
dc.date.available2017-04-19T08:58:51Z-
dc.date.issued2002-
dc.identifier.issn0096-9621-
dc.identifier.uri10.1006/abbi.2001.2691ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5756-
dc.description.abstractCellular metabolism of dopamine (DA) generates H2O2, which is further reduced to hydroxyl radicals in the presence of iron. Cellular damage inflicted by DA-derived hydroxyl radicals is thought to contribute to Parkinson's disease. We have previously developed procedures for detecting proteins that contain H2O2-sensitive cysteine (or selenocysteine) residues. Using these procedures, we identified ERP72 and ERP60, two members of the protein disulfide isomerase family, creatine kinase, glyceraldehyde-3-phosphate dehydrogenase, phospholipase C-γ1, and thioredoxin reductase as the targets of DA-derived H2O2. Experiments with purified enzymes identified the essential Cys residues of creatine kinase and glyceraldehyde-3-phosphate dehydrogenase, that are specifically oxidized by H2O2. Although the identified proteins represent only a fraction of the targets of DA-derived H2O2, functional impairment of these proteins has previously been associated with cell death. The oxidation of proteins that contain reactive Cys residues by DA-derived H2O2 is therefore proposed both to be largely responsible for DA-induced apoptosis in neuronal cells and to play an important role in the pathogenesis of Parkinson's disease.-
dc.publisherElsevier-
dc.titleOxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cells-
dc.title.alternativeOxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cells-
dc.typeArticle-
dc.citation.titleArchives of Biochemistry and Biophysics-
dc.citation.number2-
dc.citation.endPage423-
dc.citation.startPage414-
dc.citation.volume397-
dc.contributor.affiliatedAuthorKi Sun Kwon-
dc.contributor.alternativeName김재룡-
dc.contributor.alternativeName권기선-
dc.contributor.alternativeName윤해원-
dc.contributor.alternativeName이승록-
dc.contributor.alternativeName이서구-
dc.identifier.bibliographicCitationArchives of Biochemistry and Biophysics, vol. 397, no. 2, pp. 414-423-
dc.identifier.doi10.1006/abbi.2001.2691-
dc.subject.keywordCysteine oxidation-
dc.subject.keywordDopamine toxicity-
dc.subject.keywordHydrogen peroxide-
dc.subject.keywordParkinson's disease-
dc.subject.localCysteine oxidation-
dc.subject.localDopamine toxicity-
dc.subject.localHydrogen peroxide-
dc.subject.localhydrogen peroxide-
dc.subject.localParkinson disease-
dc.subject.localParkinson's disease-
dc.subject.localParkinson’s Disease-
dc.subject.localParkinson’s disease-
dc.subject.localParkinson’s diseases-
dc.subject.localParkinsons disease (PD)-
dc.subject.localParkinsons disease-
dc.subject.localParkinson's diasease-
dc.subject.localParkinson's Disease-
dc.description.journalClassY-
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Aging Convergence Research Center > 1. Journal Articles
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