Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent

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dc.contributor.authorJong Won Choi-
dc.contributor.authorKeun Huh-
dc.contributor.authorSuk Hwan Kim-
dc.contributor.authorKyung Tae Lee-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorHee Juhn Park-
dc.date.accessioned2017-04-19T08:58:51Z-
dc.date.available2017-04-19T08:58:51Z-
dc.date.issued2002-
dc.identifier.issn03788741-
dc.identifier.uri10.1016/S0378-8741(01)00382-8ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5758-
dc.description.abstractThe stem bark of Kalopanax pictus is an anti-rheumatoidal arthritis drug in Oriental medicine. In the rheumatoidal rat, induced by Freund's complete adjuvant (FCA) reagent, we investigated the effects of hederagenin monodesmosides of K. pictus on oxidative stress and hepatic drug-metabolizing enzymes. Kalopanaxsaponin-A (KPS-A) significantly decreased malondialdehyde formation and the activities of xanthine oxidase and aldehyde oxidase of hepatic non-microsomal systems in FCA reagent-treated rats. In addition, increased activity levels of superoxide dismutase, catalase and glutathione peroxidase were also observed. The effects of KPS-A were more potent than the effects of KPS-I. These results suggested that KPS-A, extracted from K. pictus, could reduce rheumatoidal syndromes through antioxidative mechanisms.-
dc.publisherElsevier-
dc.titleKalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent-
dc.title.alternativeKalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent-
dc.typeArticle-
dc.citation.titleJournal of Ethnopharmacology-
dc.citation.number1-
dc.citation.endPage118-
dc.citation.startPage113-
dc.citation.volume79-
dc.contributor.alternativeName최종원-
dc.contributor.alternativeName허근-
dc.contributor.alternativeName김석환-
dc.contributor.alternativeName이경태-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName박희준-
dc.identifier.bibliographicCitationJournal of Ethnopharmacology, vol. 79, no. 1, pp. 113-118-
dc.identifier.doi10.1016/S0378-8741(01)00382-8-
dc.subject.keywordFreund's adjuvant reagent-
dc.subject.keywordKalopanax pictus-
dc.subject.keywordKalopanaxsaponin A-
dc.subject.keywordMicrosomal-
dc.subject.keywordOxidative stress-
dc.subject.keywordRheumatoidal arthritis-
dc.subject.localFreund's adjuvant reagent-
dc.subject.localKalopanax pictus-
dc.subject.localKalopanaxsaponin A-
dc.subject.localMicrosomal-
dc.subject.localOxidative stress-
dc.subject.localRheumatoidal arthritis-
dc.description.journalClassY-
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