DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lucio Toma | - |
dc.contributor.author | Maria Paola Giovannoni | - |
dc.contributor.author | Vittorio Dal Piaz | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.contributor.author | Young Kook Kim | - |
dc.contributor.author | Daniela Barlocco | - |
dc.date.accessioned | 2017-04-19T08:58:54Z | - |
dc.date.available | 2017-04-19T08:58:54Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0385-5414 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5774 | - |
dc.description.abstract | A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported. | - |
dc.publisher | Elsevier | - |
dc.title | Mono- and di-substituted 5,6-diphenyl-3-alkylamino-pyridazines active as ACAT inhibitors | - |
dc.title.alternative | Mono- and di-substituted 5,6-diphenyl-3-alkylamino-pyridazines active as ACAT inhibitors | - |
dc.type | Article | - |
dc.citation.title | Heterocycles | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 46 | - |
dc.citation.startPage | 39 | - |
dc.citation.volume | 57 | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.affiliatedAuthor | Young Kook Kim | - |
dc.contributor.alternativeName | Toma | - |
dc.contributor.alternativeName | Giovannoni | - |
dc.contributor.alternativeName | Piaz | - |
dc.contributor.alternativeName | 권병목 | - |
dc.contributor.alternativeName | 김영국 | - |
dc.contributor.alternativeName | Barlocco | - |
dc.identifier.bibliographicCitation | Heterocycles, vol. 57, no. 1, pp. 39-46 | - |
dc.identifier.doi | 10.3987/COM-01-9351 | - |
dc.description.journalClass | Y | - |
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