Mono- and di-substituted 5,6-diphenyl-3-alkylamino-pyridazines active as ACAT inhibitors

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dc.contributor.authorLucio Toma-
dc.contributor.authorMaria Paola Giovannoni-
dc.contributor.authorVittorio Dal Piaz-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorYoung Kook Kim-
dc.contributor.authorDaniela Barlocco-
dc.date.accessioned2017-04-19T08:58:54Z-
dc.date.available2017-04-19T08:58:54Z-
dc.date.issued2002-
dc.identifier.issn0385-5414-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5774-
dc.description.abstractA series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.-
dc.publisherElsevier-
dc.titleMono- and di-substituted 5,6-diphenyl-3-alkylamino-pyridazines active as ACAT inhibitors-
dc.title.alternativeMono- and di-substituted 5,6-diphenyl-3-alkylamino-pyridazines active as ACAT inhibitors-
dc.typeArticle-
dc.citation.titleHeterocycles-
dc.citation.number1-
dc.citation.endPage46-
dc.citation.startPage39-
dc.citation.volume57-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.affiliatedAuthorYoung Kook Kim-
dc.contributor.alternativeNameToma-
dc.contributor.alternativeNameGiovannoni-
dc.contributor.alternativeNamePiaz-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName김영국-
dc.contributor.alternativeNameBarlocco-
dc.identifier.bibliographicCitationHeterocycles, vol. 57, no. 1, pp. 39-46-
dc.identifier.doi10.3987/COM-01-9351-
dc.description.journalClassY-
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